Peritoneal Lavage Treatment in Experimental Peritonitis

Rosato, Ernest F.; Oram-Smith, Jeffrey C.; Mullis, William F.; Rosato, Francis E.

doi:10.1097/00000658-197203000-00010

Cited by 50 publications

(19 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Preliminary experiments in our labora tory with appendiceal ligation [4] and de vascularization procedures [7] resulted in a mortality within 3 days of 50% and disap pearance of intraperitoneal infection in the surviving animals. At sacrifice on the 7th day only fibrinous adhesions were found, but no purulent fluid or abscesses.…”

Section: Discussionmentioning

confidence: 98%

A Reproducible Model for Protracted Peritonitis in the Rabbit

Hesp¹,

Hendriks²,

Lubbers³

et al. 1984

Eur Surg Res

View full text Add to dashboard Cite

The intra-abdominal implantation of a gelatin capsule containing human fecal material introduces peritonitis in the rabbit. The severity of the disease and the length of survival depend on the volume of the inoculum. A 7-day survival chance varies between 45 and 92%, depending on fecal loading. All rabbits develop intra-abdominal abscesses and in the surviving animals infection persists for at least a week, allowing further study of several aspects of peritonitis.

show abstract

Section: Discussionmentioning

confidence: 98%

A Reproducible Model for Protracted Peritonitis in the Rabbit

Hesp¹,

Hendriks²,

Lubbers³

et al. 1984

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…The situation becomes un controllable by surgical procedures such as: puncture or perforation of an intestinal sec tion, intestinal elimination or blood flow in terruption, the exclusive interruption of blood supply to a part of the intestine, cecal ligature with or without puncture [7][8][9][10][11][12][13][14][15][16]. The amount of feces escaping into the abdo men is unknown.…”

Section: Discussionmentioning

confidence: 99%

Animal Model for Chronic-Abscess-Forming Peritonitis: Histology and Microbiology

Volk¹,

Schneider²,

Dämmrich³

et al. 1990

Eur Surg Res

View full text Add to dashboard Cite

Clinical experience gives evidence of the increasing importance of chronic-abscess-forming peritonitis with a general physical impairment in spite of a well-controlled abdominal situation. The number of unsolved problems led us to develop a standardized and reproducible experimental animal model, using Wistar rats. We induced peritonitis by intra-peritoneal injection of a mixture containing a capsulated strain of Bacteroides fragilis and DEV agar. The histologic changes in the parietal and visceral peritoneum, lymphnodes and liver were recorded in the course of the disease. The data largely correlate with those recorded in human peritonitis. Bacteriologic examinations gave evidence of bacteria passing through the intestinal wall into the abdomen. This is the first model for peritonitis which is defined by its histological and bacteriological course. It enables one to examine pathophysiological problems and the consequences of harm and stress for the course of the disease.

show abstract

“…A proposed benefit'of heparin is prevention of intra-abdominal adhesion formation (Parker er al 1987) which may cause small intestinal obstruction after exploratory celiotomy in horses (Huskamp and Bonfig 1986;Baxter and Moore 1988). Tissue ischaemia is one of the most potent stimuli to production of such adhesions (Ellis 1962;Sullins, Stashak and Mero 1985) and surgical models have been used to induce ischaemia and study septic peritonitis in other species (Rosato, Oram-Smith, Mullis and Rosato 1972;Davidson, Cardenas and Busuttil 1981). This demonstrated improved survival following heparin administration (Hau and Simmons 1978; and Wickbom 1988).…”

Section: Discussionmentioning

confidence: 99%

The effect of low dose heparin therapy on complication and survival rates in horses following exploratory celiotomy

Young

Richardson

Markel

1989

Equine Veterinary Journal

View full text Add to dashboard Cite

Summary A randomised, blind prospective study was performed to evaluate effects of low dose heparin therapy on complication and survival rates in 33 horses following exploratory celiotomy. Four horses had non‐strangulating lesions and seven had strangulating lesions of the small intestine, 19 had non‐strangulating lesions of the large intestine, and three had duodenitis‐proximal jejunitis. Eighteen required an enterotomy or intestinal resection and anastomosis. Sixteen received heparin subcutaneously (66 iu/kg every 12 h) post operatively and 17 received a saline placebo for a mean of 3.7 days. There was a significant (P<0.01) mean decrease in PCV (29.1 per cent) in the heparin group. No significant differences in complication or survival rates were seen between groups. Long term follow‐up was obtained for 10 horses in each group. There were no significant differences between groups.

show abstract

Peritoneal Lavage Treatment in Experimental Peritonitis

Cited by 50 publications

References 2 publications

A Reproducible Model for Protracted Peritonitis in the Rabbit

A Reproducible Model for Protracted Peritonitis in the Rabbit

Animal Model for Chronic-Abscess-Forming Peritonitis: Histology and Microbiology

The effect of low dose heparin therapy on complication and survival rates in horses following exploratory celiotomy

Contact Info

Product

Resources

About