Peritoneal Effects of Prosthetic Meshes Used to Repair Abdominal Wall Defects: Monitoring Adhesions by Sequential Laparoscopy

Bellón, Juan M.; Rodrı́guez, Marta; García‐Honduvilla, Natalio; Pascual, Gemma; Gil, Verónica Gómez; Buján, Julia

doi:10.1089/lap.2006.0028

Cited by 51 publications

(34 citation statements)

References 14 publications

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“…The defect area after three weeks ranged from 32.1±5.5 to 35.6±3.1 squared centimeters and was similar to other reports that made only the acute full-thickness defect with areas ranging from 35 to 40 squared centimeters 9,10,18,[30][31][32][33][34][35][36][37][38] . The hypothetic advantage of our model was to simulate the surgical findings in the human hernia repair.…”

Section: Discussionsupporting

confidence: 86%

Animal model of chronic abdominal hernia in rabbit

Silva

Fagundes

Seidel³

et al. 2009

Acta Cir. Bras.

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Purpose: To create a feasible animal model of hernia that should be reliable to test the different types of mesh and/or surgical technique. Methods: Thirty six male New Zealand albino rabbits were submitted to surgical procedure to provoke a standard hole in the abdominal wall. A metallic frame measuring 3 cm length and 1 cm width was allocated longitudinally on the umbilicus scar and the comprehensive three squared centimeters area was resected. A continuous 4.0 polyamide was performed to closure the subcutaneous and skin. Results: During three weeks a score of signals/symptoms was performed to evaluate the wound and clinical conditions. No death or severe complications occurred. In the 3rd week the hernia ring and visceral adhesions were evaluated. Soft omental adherences were present in the hernial sac in all animals. The area of hernia ring ranged from 32.1±5.5 to 35.6±3.1 squared centimeter and the maximum was 39 cm 2 and the minimum was 30 cm 2 . The model results in protrusion which was similar to a human incisional hernia with hernia sac, visceral adhesions and fibrous healing ring. Conclusion: The model was more reliable to test further techniques or mesh on hernia repair. Key words: Hernia, Ventral. Hernia, Abdominal. Wound Healing. Animal Experimentation. Rabbits. RESUMO Objetivo:Criação de um modelo animal de hérnia que seja confiável para testar as diferentes técnicas e tipos de telas. Métodos: Trinta e seis coelhos foram submetidos a procedimento operatório que provocou uma falha na parede abdominal. Uma moldura metálica com 3 cm de comprimento e 1 cm de largura foi colocada longitudinalmente sobre a cicatriz umbilical e ressecada uma área de 3cm 2 . Uma sutura contínua de poliamida 4.0 fechou a tela subcutânea e pele. Resultados: durante três semanas o escore de sinais e sintomas foi coletado para avaliar as condições clínicas e da ferida operatória. Não ocorreram óbitos ou complicações graves. Na terceira semana o anel herniário e aderências peritoneais foram avaliadas. Aderências frouxas estavam presentes no saco herniário em todos os animais. A área do anel herniário variou de 32.1±5.5 a 35.6±3.1 cm 2 , com um máximo de 39 cm 2 e um mínimo de 30 cm 2 . O modelo resultou numa protrusão de vísceras semelhante ao que ocorre em hérnia incisional de humanos. Conclusão: O modelo é factível para testar técnicas operatórias ou telas na reconstrução de hérnias incisionais.

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Section: Discussionsupporting

confidence: 86%

Animal model of chronic abdominal hernia in rabbit

Silva

Fagundes

Seidel³

et al. 2009

Acta Cir. Bras.

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“…Hence, the use of surgical meshes for correction of abdominal hernias was strengthened due to its lower recurrence rates [6][7][8][9][10][11][12][13][14] . With the advent of laparoscopic surgery and the placement of intraperitoneal meshes, major adhesion formation was highlighted 2,7,[14][15][16][17][18][19] . The composite meshes -which have the surface facing the viscera made of absorbable and microporous material and the surface facing the muscles made of synthetic macroporous material -are the ones with the best results 20,21 .…”

Section: ■ Introductionmentioning

confidence: 99%

“…The search for the ideal composition became necessary with the introduction and development of laparoscopic repair of abdominal hernias, which required intraperitoneal mesh fixation 4,22 . Among the surgical meshes available on the market, the polypropylene ones are the most commonly used nowadays 4,16,18 . Polypropylene is a carbon-based materialwhich can be monofilament or multifilament -of easy handling, low cost, and non-biodegradable.…”

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confidence: 99%

Comparative study of Polypropylene versus Parietex composite®, Vicryl® and Ultrapro® meshes, regarding the formation of intraperitoneal adhesions

et al. 2017

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Purpose: To compare the polypropylene mesh (Marlex®) to Vicryl®, Parietex composite® and Ultrapro® meshes to assess the occurrence of adhesions in the intraperitoneal implantation. Methods: Sixty Wistar rats were allocated into three groups: PP+V, in which all the animals received a polypropylene and a Vicryl® mesh; PP+PC, with the implantation of polypropylene and Parietex composite® meshes and PP+UP, in which there was implantation of polypropylene and Ultrapro®. Macroscopic analysis was performed 28 days later to assess the percentage of mesh area affected by adhesion. Results: in the PP+ V group, the Vicryl® mesh showed lower adhesion formation (p=0.013). In the PP+PC, there were no differences between polypropylene and Parietex composite® (p=0.765). In the PP+UP group, Ultrapro® and polypropylene meshes were equivalent (p=0.198). Conclusion: All the four meshes led to adhesions, with the Vicryl® mesh showing the least potential for its formation.

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“…When inserted intraperitoneally, in general a mesh induces a foreign body reaction and the Experimental studies with surgical meshes for evaluation of biocompatibility and adhesion formation use animal models, such as rabbits [23][24][25] , sheep 26 , pigs 15 , and, especially, rats 11,27 . The variables analyzed include incidence, extent, quality and, in some studies, resistance to rupture and tenacity.…”

Section: Discussionmentioning

confidence: 99%

“…As of incorporation, there were no significant differences between the meshes. Bellón et al 25 analyzed the polypropylene with poliglecaprone mesh and other prostheses in the correction of defects of the abdominal wall in rabbits.…”

Section: Discussionmentioning

confidence: 99%

Comparison between polypropylene and polypropylene with poliglecaprone meshes on intraperitoneal adhesion formation

Biondo-Simões

Schiel

Arantes

et al. 2016

Rev. Col. Bras. Cir.

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Objective: to compare intraperitoneal adhesion formation in rats when using polypropylene and polypropylene with poliglecaprone meshes. Methods: we used twenty male, Wistar rats, divided in two groups. In group 1, the rats received the polypropylene mesh on their right side and the polypropylene with poliglecaprone mesh on their left side. In group 2 the position of the meshes was inverted. After 30 days, we analyzed the presence or not of adhesion formation, including only those over the meshes. The findings undergone an analysis through the Mann-Whitney test, at a level of significance of p≤0.05. Results: all meshes presented adhesions. We verified that, for the polypropylene meshes, the percentage of their surface covered by adhesions varied from 10.5 to 100%, with an average of 34.07±24.21%, while for the polypropylene with poliglecaprone mesh, the percentage covered by adhesions varied between 8.5% and 100%, with an average of 44.7±32.85% (p=0.12). Conclusion: both meshes lead to adhesion formation, none being superior to the other.

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Peritoneal Effects of Prosthetic Meshes Used to Repair Abdominal Wall Defects: Monitoring Adhesions by Sequential Laparoscopy

Cited by 51 publications

References 14 publications

Animal model of chronic abdominal hernia in rabbit

Animal model of chronic abdominal hernia in rabbit

Comparative study of Polypropylene versus Parietex composite®, Vicryl® and Ultrapro® meshes, regarding the formation of intraperitoneal adhesions

Comparison between polypropylene and polypropylene with poliglecaprone meshes on intraperitoneal adhesion formation

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