In this study, we present the new investigations on the combined effect of partial slip and nanofluid on the peristaltic transport of a Jeffrey fluid model in an asymmetric channel. Mathematical formulation of the present problem is first given and then simplified under the conjecture of long wave length and low Reynolds number approximation. The homotopy perturbation technique is used to calculate the solution of the coupled nonlinear equations of temperature and nanoparticle volume fraction. The exact solution of the momentum equation is calculated using the solutions of temperature and nanoparticle volume fraction. In the end, the graphical results of the proposed problem are discussed to study the behavior of the emerging parameters.Index Terms-Nanofluid, partial slip, peristaltic flow and Jeffrey fluid model.