Periprosthetic joint infection

Kapadia, Bhaveen H.; Berg, Richard A.; Daley, Jacqueline A.; Fritz, Jan; Bhave, Anil; Mont, Michael A.

doi:10.1016/s0140-6736(14)61798-0

Cited by 644 publications

(520 citation statements)

References 102 publications

Supporting

Mentioning

479

Contrasting

Unclassified

Order By: Relevance

“…Over the past few decades, bacteremia rates have been 20-38%, and this rate jumps to > 100 for people over the age of 70. S. aureus is the pathogen that is most frequently involved in combined infections (13)(14)(15)(16). The current study investigated the ability of SFJDC to prevent death from an S. aureus infection in mice.…”

Section: Prevention Of Death From An S Aureus Infection With Sfjdc Imentioning

confidence: 99%

Effect of Shufeng Jiedu capsules as a broad-spectrum antibacterial

Bao

Gao

Cui

2016

BST

View full text Add to dashboard Cite

Section: Prevention Of Death From An S Aureus Infection With Sfjdc Imentioning

confidence: 99%

Effect of Shufeng Jiedu capsules as a broad-spectrum antibacterial

Bao

Gao

Cui

2016

BST

View full text Add to dashboard Cite

“…Cobo ve arkadaşlarının yaptığı 117 (46 diz, 57 kalça protezi) hastalık bir çalışmada 2.5 aylık tedavi ile %53.7 oranında başarı sağlanmıştır [31] . Capadia ve arkadaşlarının derlemesinde iki basamaklı replasmanda altı haftalık tedavi süresinin yeterli olduğu görülmüş ve yeni protez takılmadan önce tamamen iyileşmenin görülmesi için 2-4 haftalık antibiyotiksiz bir zaman gerekliliği söylenmiştir [32] .…”

Section: Tablo 4 Operasyon Sonrası Metisiline Dirençliunclassified

Causative Pathogens at Hip and Knee Prosthetic Joint Infections, Treatment Regimens and Evaluation of Prognosis

Ulu¹,

Şele²,

Kuşçu³

et al. 2016

FLORA

View full text Add to dashboard Cite

ÖZET GİRİŞHer yıl tüm dünyada bir milyondan fazla kalça protezi yapılmakta ve pek çok insan protez eklemlerle hayatını sürdürmektedir. Gerek travma gerekse de malignite ve artroza bağlı olarak fonksiyonları ileri derecede bozulmuş eklemlerde oldukça başarılı sonuçlar alınmakta ve hastaların hayat kalitesi artmaktadır. Antimikrobiyal profilaksi ve laminar akımlı cerrahi ortamlar intraoperatif infeksiyon riskini azaltmaktadır. Ancak antimikrobiyal tedavilerdeki ve ortopedideki tüm gelişmelere rağmen halen en korkulan komplikasyonlardan biri infeksiyonlardır. İnfeksiyon çoğu kez protezin çıkarılmasına ve eklem fonksiyon kaybına yol açar ve mortalite oranı %2.7-18 arasındadır [1,2] . İnfek-siyon, ortalama hastanede kalış süresini uzatmakta ve hastanın çoğu kez birden fazla ameliyat geçirmesini gerektirmektedir. Uzun süreli antibiyotik tedavisi ve bazen de süpresyon tedavileri nedeniyle de tedavi maliyeti ciddi oranda artmaktadır.Protez infeksiyonlarında konak, yara yeri, ameliyathane ortamı, operatif teknik ve etken mikroorganizmanın özellikleri infeksiyon riski açısından önem taşır. Protez konulan bölgelerin yakınına önceden herhangi bir cerrahi işlem uygulanması, romatoid artrit (RA) ve diabetes mellitus (DM), yetersiz beslenme, ileri yaş ve şişmanlık gibi bazı predispozan faktörler bulunmaktadır [3] . Protez infeksiyonu tanısında altın standart kültürdür. Etkenin izole edilmesi adına uygun ve zamanında örnekleme yapılması önemlidir. Dokunun durumu ve izole edilen patojenin türü ise protez eklem infeksiyonlarının tedavisini şekillendirmektedir.

show abstract

“…3,7,8 This number is higher if only instrumented surgeries are considered. The majority of the evidence on infection surrounding implants comes from arthroplasty literature; [9][10][11][12][13] however, the principles remain applicable. The major surgical decision in periprosthetic joint infections relies on the timing of infection: if presenting acutely, then the implants may be debrided and retained.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Implant Retention and Antibiotic Suppression in Instrumented Spine Infections: A Preliminary Data Set of 67 Patients

et al. 2018

View full text Add to dashboard Cite

Background: It is unclear whether patients can be taken off suppressive antibiotics with infected retained instrumentation. This study aimed to retrospectively analyze the perioperative course and antibiotic regimen that led to the clinical intervention of patients with infected spinal instrumentation.Methods: Consecutive adult patients with spine instrumentation who suffered surgical site infections (SSI) requiring debridement were retrospectively analyzed. The patients were grouped into 4 cohorts based on their clinical intervention: removal of instrumentation, reinstrumentation, retention of instrumentation with continued antibiotic suppression, and retention of instrumentation with no antibiotic suppression. Patient factors, infection factors, debridement, and antibiosis were compared.Results: Of the 67 patients with SSI after spine surgery and instrumentation, 19 (28%) had their instrumentation removed, 6 (9%) had their instrumentation exchanged, 25 (37%) had their instrumentation retained and were on antibiotic suppression, and 17 (25%) had their instrumentation retained without any suppression. Those who had their instrumentation removed had a later presentation of their infection averaging 85 days (range 6-280 days) postoperatively. There was an earlier presentation for those who retained their implants, with suppression averaging 19 days (range 9-39) and no suppression averaging 29 days (range 6-90 days) post operatively (P , .001).Conclusions: None of the patients with retained instrumentation without suppression had recurrence of infections after long-term follow-up. Lifelong antibiotic suppression may not be required with SSI that present early after early aggressive debridement. Patients with infections detected later are difficult to treat without removal of their original instrumentation.Clinical Relevance: This study presents the outcomes of surgical and antibiotic factors in patients with infected spinal instrumentation.

show abstract

Periprosthetic joint infection

Cited by 644 publications

References 102 publications

Effect of Shufeng Jiedu capsules as a broad-spectrum antibacterial

Effect of Shufeng Jiedu capsules as a broad-spectrum antibacterial

Causative Pathogens at Hip and Knee Prosthetic Joint Infections, Treatment Regimens and Evaluation of Prognosis

An Analysis of Implant Retention and Antibiotic Suppression in Instrumented Spine Infections: A Preliminary Data Set of 67 Patients

Contact Info

Product

Resources

About