Peripheral sympathetic function as a predictor of complex regional pain syndrome type I (CRPS I) in patients with radial fracture

Schürmann, Martin; Gradl, Georg; Zaspel, Johannes; Kayser, Martin; Löhr, Pascal; Andreß, H.-J.

doi:10.1016/s1566-0702(00)00250-2

Cited by 83 publications

(53 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analysing the studies about incidence in patients with Fractures of Distal Radius (FDR) a variability from 0 to 37% can be found (24)(25)(26)(27). This difference can be explained by the different criteria used in the CRPS classification and by the different populations taken in exam.…”

Section: Fractures Of Distal Radiusmentioning

confidence: 99%

“…This difference can be explained by the different criteria used in the CRPS classification and by the different populations taken in exam. CRPS occurring after FDR is more common in elderly patients with psychological or psychiatric conditions (28) but not all Authors agree regarding physiological factors as predictors of CRPS incidence (27) in this kind of trauma. Additionally, in a case control study, it was found a higher possibility to develop CRPS I after fracture in patients with social life adverse events compared to the control group (29).…”

Section: Fractures Of Distal Radiusmentioning

confidence: 99%

See 1 more Smart Citation

Post-traumatic complex regional pain syndrome: clinical features and epidemiology

Ratti

Nordio

Resmini

et al. 2015

ccmbm

View full text Add to dashboard Cite

SummaryComplex Regional Pain Syndrome (CRPS) is a chronic pain condition that occurs after a tissue injury (fractures, sprain, surgery) of the upper or lower extremities. A clear pathophysiological mechanism has not been established yet and different patterns are considered to play a role in the genesis of the disease. The diagnosis is made by different diagnosis criteria and a gold standard has not been established yet. Incidence of CRPS is unclear and large prospective studies on the incidence and prevalence of CRPS are scarce. The aim of this review is to give an overview on the prevalent data regarding this chronic syndrome.

show abstract

Section: Fractures Of Distal Radiusmentioning

confidence: 99%

Section: Fractures Of Distal Radiusmentioning

confidence: 99%

Post-traumatic complex regional pain syndrome: clinical features and epidemiology

Ratti

Nordio

Resmini

et al. 2015

ccmbm

View full text Add to dashboard Cite

show abstract

“…45,77,95 This findings leads to the important conclusion that CRPS cannot depend on enhanced activity in sympathetic efferent fibers, at least not at stages during which the activity is blunted. It also supports the theory that latephase CRPS (when the limb is often cold and cyanotic) may depend on denervation hypersensitivity of sympathetic vasoconstrictors, 27,53,89 a phenomenon that would be expected if sympathetic activity is blunted for prolonged periods.…”

Section: If Not Sympathetically Maintained Pain Then What?mentioning

confidence: 94%

Complex Regional Pain Syndrome: What's in a Name?

Coderre

2011

The Journal of Pain

View full text Add to dashboard Cite

Within a two year period in the 1940's, two Boston physicians published dramatically opposing views on the underlying nature of a syndrome now known as complex regional pain syndrome (CRPS). Evans suggested, in several papers in [1946][1947], that sympathetic reflexes maintain pain and dystrophy in affected limbs. Foisie, in 1947, suggested arterial vasospasms were key in the etiology of this pain syndrome. Evans' hypothesis established the nomenclature for this syndrome for 60 years, and his term "reflex sympathetic dystrophy" guided clinical treatment and research activities over the same period. Foisie's proposed nomenclature was unrecognized, and had virtually no impact on the field. Recent evidence suggests that Evans' contribution to the field may have in fact lead clinicians and researchers astray all those years. This focus article on CRPS compares recent observations with these 2 earlier theories and asks the question --what if we had adopted Foisie's nomenclature from the beginning?

show abstract

“…Not necessarily over-activity of the sympathetic system is responsible. In a prospective study in humans reduced sympathetic activity was observed before the onset of CRPS, both the affected and the unaffected, suggesting systemic alterations in sympathetic regulation rapidly after injury [14] end; this change is a higher risk of CRPS. This reduction in sympathetic activity is associated with the initial stage where the patient is warm and red tip; othe studies indicate that in chronic phase occurs decrease in endothelium-dependent vasodilation and altered levels of endothelin, nitric oxide and nitric oxide synthase [10].…”

Section: Alteration Of Cutaneous Innervation After Traumamentioning

confidence: 96%

Infliximab Management Complex Regional Pain Syndrome

2015

JACCOA

View full text Add to dashboard Cite

The role of inflammatory mechanisms in the pathogenesis of CRPS is important and that makes it a target that must meet every day. Infliximab is a molecule that has been used in the management of CRPS and published case reports and two studies showing improvement in range of motion, differences in temperature and decrease pain persist even phenomena of peripheral and Central after a few months; as same adverse reactions have been reported including appearance of CRPS in patients who received other necessary conditions and use with caution. The information is so far low level of evidence for such studies from which it was generated so it is necessary to have higher quality studies to obtain more solid conclusions. SummaryThe complex regional pain syndrome (CRPS) is a variety of painful conditions of regional finding, after an injury, with distal predominance with symptoms that exceed in magnitude and duration the expected clinical course, with motor impairment and progressive course. Within the pathophysiology of complex regional pain syndrome multiple factors that produce and therefore proposed treatments are evaluated current evidence is recognized. One mechanism proposed that may contribute to the occurrence of CRPS is a tumor necrosis factor, TNFa, and a therapeutic proposal is the use of monoclonal antibody TNFa inhibitor, infliximab. The aim is to review aspects of diagnosis, pathophysiology and current evidence on the use of infliximab in CRPS.

show abstract

Peripheral sympathetic function as a predictor of complex regional pain syndrome type I (CRPS I) in patients with radial fracture

Cited by 83 publications

References 33 publications

Post-traumatic complex regional pain syndrome: clinical features and epidemiology

Post-traumatic complex regional pain syndrome: clinical features and epidemiology

Complex Regional Pain Syndrome: What's in a Name?

Infliximab Management Complex Regional Pain Syndrome

Contact Info

Product

Resources

About