Peripheral serotonin and tryptophan levels in rats under progesterone long-term administration

Aleksandrov, A. V.; Konopelniuk, V.; Ostapchenko, L.

doi:10.17721/2616_6410.2016.20.5-7

Cited by 2 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Progesterone withdrawal resulted in depression-like behavior in rodents without altering serotonin levels or serotonin metabolism centrally or peripherally, and this depression-like behavior was not remedied with fluoxetine administration [ 70 ]. In rats, daily progesterone administration over 28 days resulted in an increase in both tryptophan and serotonin in the duodenal mucosa (2.1 fold and 1.5 fold, respectively) as well as an increase of tryptophan and serotonin in serum (1.5 fold and 4.1 fold, respectively) [ 71 ]. When ovariectomized rodents were administered 17β-estradiol, a decrease in depression-like behavior was observed.…”

Section: The Peripartal Periodmentioning

confidence: 99%

The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad

Fricke

Hernández

2023

J Mammary Gland Biol Neoplasia

View full text Add to dashboard Cite

Lactation is a physiological adaptation of the class Mammalia and is a product of over 200 million years of evolution. During lactation, the mammary gland orchestrates bone metabolism via serotonin signaling in order to provide sufficient calcium for the offspring in milk. The role of serotonin in bone remodeling was first discovered over two decades ago, and the interplay between serotonin, lactation, and bone metabolism has been explored in the years following. It is estimated that postpartum depression affects 10–15% of the population, and selective serotonin reuptake inhibitors (SSRI) are often used as the first-line treatment. Studies conducted in humans, nonhuman primates, sheep, and rodents have provided evidence that there are consequences on both parent and offspring when serotonin signaling is disrupted during the peripartal period; however, the long-term consequences of disruption of serotonin signaling via SSRIs during the peripartal period on the maternal and offspring skeleton are not fully known. This review will focus on the relationship between the mammary gland, serotonin, and bone remodeling during the peripartal period and the skeletal consequences of the dysregulation of the serotonergic system in both human and animal studies.

show abstract

Section: The Peripartal Periodmentioning

confidence: 99%

The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad

Fricke

Hernández

2023

J Mammary Gland Biol Neoplasia

View full text Add to dashboard Cite

show abstract

“…Співвідношення триптофану до комплекcу з альбуміном залежить від концентрації у cироватці крові вільних жирних киcлот, які також здатні зв'язуватиcя з альбуміном і тим cамим витіcняти триптофан із комплекcу з альбуміном. У наших попередніх дослідженнях установлено підвищення концентрацій триптофану та серотоніну в сироватці крові у щурів за умов довготривалого введення прогестерону порівняно із контрольною групою тварин [18]. Таким чином, витіснення триптофану із комплекcу триптофан-альбумін вільними жирними киcлотами може розглядатиcя як ще одна причина збільшення вміcту вільного триптофану в крові щурів та у мозку за умов довготривалого введення прогестерону.…”

unclassified

Pathway in rat brains under experimental obesity caused long-term progesterone administration

et al. 2018

Self Cite

View full text Add to dashboard Cite

Obesity is one of the most common complex health problem. The pathway of serotonin synthesis takes part in neuroendocrine regulation, as well as in the regulation of a number of behavioral functions of the body and fat deposition. Serotonin is a mediator of the amine nature, which functions as a neurotransmitter and tissue hormone. The greatest amount of serotonin is synthesized in the brain and 12 duodenum. As a neurotransmitter, serotonin affects both directly and indirectly on the function of most brain cells. Female hormone progesterone influence on serotonin functions. One of the effect of progesterone is increasing of amount of fat tissue during the pregnancy. Long-term using of progesterone in hormone substitution therapy or as part of contraception also lead to fat accumulation effect. The levels of activity of serotonergic system enzymes, tryptophan hydroxylase, tryptophan decarboxylase and monoamine oxidase (MAO), and tryptophan, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid concentrations in the rat brain under obesity conditions caused by prolonged administration of progesterone were determined in this study. Studies have shown that the content of tryptophan, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in the brain of rats under obesity caused by prolonged administration of progesterone increased in comparison with the rats of the control group. The levels of tryptophan hydroxylase and MAO activity decreased, and tryptophan decarboxylase activity levels increased in the rat brain under obesity conditions caused by prolonged administration of progesterone. Thus, as a result of our studies, we found an imbalance in the system of serotonin metabolism in the brain of rats with the development of hormonal obesity induced by prolonged administration of progesterone, which may indicate the involvement of the serotonergic neurotransmitter system in the mechanisms of the development of obesity and concomitant diseases.

show abstract

Peripheral serotonin and tryptophan levels in rats under progesterone long-term administration

Cited by 2 publications

References 12 publications

The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad

The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad

Pathway in rat brains under experimental obesity caused long-term progesterone administration

Contact Info

Product

Resources

About