Peripheral neuropathy is associated with increased mean platelet volume in type 2 diabetic patients

Παπάνας, Νικόλαος; Mavridis, G.; Karavageli, E.; Symeonidis, G.; Maltezos, Efstratios

doi:10.1080/09537100500384723

Cited by 13 publications

(12 citation statements)

References 8 publications

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“…Moreover, MPV is higher in type 2 diabetic patients than in nondiabetic patients, moreover, it was higher in diabetic patients who have microvascular complications (retinopathy or microalbuminuria). Also, increased MPV is associated with presence of neuropathy in patients with type 2 diabetes mellitus .The levels of inflammatory proteins including cytokines and among these TNF‐ α, IL‐6 or CRP, are increased in COPD patients, this systemic inflammation is associated with various complications in COPD, including cardiovascular and metabolic diseases such as diabetes . IL‐6 and CRP have been shown to increase the risk of developing new‐onset type 2 diabetes; especially the high levels of CRP may predict its development .…”

Section: Discussionmentioning

confidence: 99%

Platelet function in diabetic and nondiabetic patients with chronic obstructive pulmonary disease: a case control study

Makhlouf

Sadek

Nafady

2016

Clinical Respiratory J

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Section: Discussionmentioning

confidence: 99%

Platelet function in diabetic and nondiabetic patients with chronic obstructive pulmonary disease: a case control study

Makhlouf

Sadek

Nafady

2016

Clinical Respiratory J

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“…Secondary risk factors are smoking and prediabetes [1,21,60,63]. Platelet activation [79][80][81][82], oxidative stress [65][66][67][68][69][70][71][72][73][74], low vitamin D [83,84], insulin resistance [58], and genetic factors [100][101][102][103][104][105][106] play another supplementary role, but, for the time being, there are limited options for intervention. A suggestion for targeting insulin resistance originates from the study by Pop-Busui et al, showing that reduced incident DSPN is less frequent in T2D patients receiving insulin-sensitizing oral agents (66%) than in those receiving insulinproviding treatment (66% vs. 72%, respectively, p = 0.02) [155].…”

Section: Discussionmentioning

confidence: 99%

“…Mean platelet volume (MPV) is a marker of platelet activation, and may be increased in diabetes patients, especially in the context of microvascular complications [80]. Elevated MPV has indeed been reported in T2D patients with DSPN [81,82].…”

Section: Platelet Activationmentioning

confidence: 99%

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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■ AbstractDistal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral artery disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.

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“…Increased MPV has been demonstrated in diabetes (3)(4)(5)(6)(7)(8)(9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10)(11)(12)(13)(14)(15)(16)(17), diabetic neuropathy (18)(19)(20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3)(4)(5)26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing 2012.…”

Section: Introductionmentioning

confidence: 99%

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Güngör¹,

Gürsoy

Güngör³

et al. 2016

Turk J Med Sci

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IntroductionDiabetes mellitus (DM), a major global health problem, is commonly associated with increased risk of developing micro-and macrovascular disease. Despite its clinical importance, the pathophysiology of diabetic complications is not completely understood. Platelets have been thought to be involved in these complications. Diabetic retinopathy (DR) is one of those important complications and leads to a considerable increase in morbidity.Platelet volume is a marker of platelet activation and function that can be measured easily as mean platelet volume (MPV) by clinical analyzers. It is now known that larger platelets are more reactive and produce more prothrombotic factors (1,2). Increased MPV has been demonstrated in diabetes (3-9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10-17), diabetic neuropathy (18-20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3-5,26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing the production of more prothrombotic factors, or causing endothelium-dependent vasomotor dysfunction.Keeping in mind these complex relations between MPV, diabetes, and its complications, in the present study we aimed to: 1) compare the MPV in diabetic patients with that in healthy controls; 2) determine if there is a difference in MPV between diabetic patients with and without DR, and also with and without proliferative retinopathy; 3) compare MPV levels of diabetic patients with or without hypertension (HTA), hyperlipemia (HL), and HTA with HL, and 4) see if there is a correlation of MPV with HbA1c and body mass index (BMI) in diabetic patients. Material and methods PatientsA total of 102 type 2 DM (T2DM) patients [65 female (63.7%), 35 male (36.3%)], 50 of them without retinopathy [31 female (62.0%), 19 male (38.0%)] and 52 with retinopathy [34 female (65.4%), 18 male (34.6%)], aged 22-90 years, were recruited from the Clinic of Ankara Education and Research Hospital from June 2009 to June Background/aim: Patients with diabetes mellitus have an increased risk of developing micro-and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy.Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then checked to see if the mean platelet volume correlated with hemoglobin A1c and body mass index. Results:The mean platelet volume levels were higher in all diabetic patients, and they were highest in diabetics with retinopathy. The mean plate...

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Peripheral neuropathy is associated with increased mean platelet volume in type 2 diabetic patients

Cited by 13 publications

References 8 publications

Platelet function in diabetic and nondiabetic patients with chronic obstructive pulmonary disease: a case control study

Platelet function in diabetic and nondiabetic patients with chronic obstructive pulmonary disease: a case control study

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

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