Peripheral Neuropathy as the First Clinical Manifestation of Wegener Granulomatosis

Vasculitic Tibial Mononeuropathy Associated with Inherited Immune Dysregulation: A Review of Tibial Mononeuropathies with Electrodiagnostic Considerations

“…Systemic vasculitides are a group of diseases that involve the inflammation of blood vessels. Peripheral neuropathies such as mononeuropathy multiplex (single or multiple) or distal symmetric polyneuropathy can manifest at the onset of illness and be present in over half of small-vessel vasculitis cases [10,11]. Moreover, neuropathy can be one of the first clinical features of systemic vasculitis.…”

Vasculitic Tibial Mononeuropathy Associated with Inherited Immune Dysregulation: A Review of Tibial Mononeuropathies with Electrodiagnostic Considerations

“…Systemic vasculitides are a group of diseases that involve the inflammation of blood vessels. Peripheral neuropathies such as mononeuropathy multiplex (single or multiple) or distal symmetric polyneuropathy can manifest at the onset of illness and be present in over half of small-vessel vasculitis cases [10,11]. Moreover, neuropathy can be one of the first clinical features of systemic vasculitis.…”

P-ANCA vasculitic neuropathy with 12-year latency between onset of neuropathy and systemic symptoms

“…[8] However, in the context of a neuropathy with characteristic features of a vasculitic neuropathy, its value is likely higher, and a recent report and accompanying editorial recommended that ANCA testing be considered in the evaluation of idiopathic neuropathies. [9]…”

Primary and secondary vasculitic neuropathy

“…Wegener granulomatosis (WG) is an antibody-mediated autoimmune, granulomatous vasculitis, in which antibodies against proteinase 3 and myeloperoxidase are demonstratable in the serum of patients [16,23,47,49]. Serological demonstration of these ANCAs is a sensitive and specific means by which to diagnose WG, provided a positive result on a screening leukocyte indirect immunofluorescence microscopic ANCA study is followed up by enzyme linked immunoabsorbent assay demonstration of antiproteinase 3 and antimyeloperoxidase [49].…”

“…Serological demonstration of these ANCAs is a sensitive and specific means by which to diagnose WG, provided a positive result on a screening leukocyte indirect immunofluorescence microscopic ANCA study is followed up by enzyme linked immunoabsorbent assay demonstration of antiproteinase 3 and antimyeloperoxidase [49].…”

Vasculitic Tibial Mononeuropathy Associated with Inherited Immune Dysregulation: A Review of Tibial Mononeuropathies with Electrodiagnostic Considerations

“…Systemic vasculitides are a group of diseases that involve the inflammation of blood vessels. Peripheral neuropathies such as mononeuropathy multiplex (single or multiple) or distal symmetric polyneuropathy can manifest at the onset of illness and be present in over half of small-vessel vasculitis cases [10,11]. Moreover, neuropathy can be one of the first clinical features of systemic vasculitis.…”

P-ANCA vasculitic neuropathy with 12-year latency between onset of neuropathy and systemic symptoms

“…[8] However, in the context of a neuropathy with characteristic features of a vasculitic neuropathy, its value is likely higher, and a recent report and accompanying editorial recommended that ANCA testing be considered in the evaluation of idiopathic neuropathies. [9]…”

Primary and secondary vasculitic neuropathy

“…Wegener granulomatosis (WG) is an antibody-mediated autoimmune, granulomatous vasculitis, in which antibodies against proteinase 3 and myeloperoxidase are demonstratable in the serum of patients [16,23,47,49]. Serological demonstration of these ANCAs is a sensitive and specific means by which to diagnose WG, provided a positive result on a screening leukocyte indirect immunofluorescence microscopic ANCA study is followed up by enzyme linked immunoabsorbent assay demonstration of antiproteinase 3 and antimyeloperoxidase [49].…”

“…Serological demonstration of these ANCAs is a sensitive and specific means by which to diagnose WG, provided a positive result on a screening leukocyte indirect immunofluorescence microscopic ANCA study is followed up by enzyme linked immunoabsorbent assay demonstration of antiproteinase 3 and antimyeloperoxidase [49].…”

Vasculitic Tibial Mononeuropathy Associated with Inherited Immune Dysregulation: A Review of Tibial Mononeuropathies with Electrodiagnostic Considerations

“…Systemic vasculitides are a group of diseases that involve the inflammation of blood vessels. Peripheral neuropathies such as mononeuropathy multiplex (single or multiple) or distal symmetric polyneuropathy can manifest at the onset of illness and be present in over half of small-vessel vasculitis cases [10,11]. Moreover, neuropathy can be one of the first clinical features of systemic vasculitis.…”

P-ANCA vasculitic neuropathy with 12-year latency between onset of neuropathy and systemic symptoms

“…[8] However, in the context of a neuropathy with characteristic features of a vasculitic neuropathy, its value is likely higher, and a recent report and accompanying editorial recommended that ANCA testing be considered in the evaluation of idiopathic neuropathies. [9]…”

Primary and secondary vasculitic neuropathy

“…Wegener granulomatosis (WG) is an antibody-mediated autoimmune, granulomatous vasculitis, in which antibodies against proteinase 3 and myeloperoxidase are demonstratable in the serum of patients [16,23,47,49]. Serological demonstration of these ANCAs is a sensitive and specific means by which to diagnose WG, provided a positive result on a screening leukocyte indirect immunofluorescence microscopic ANCA study is followed up by enzyme linked immunoabsorbent assay demonstration of antiproteinase 3 and antimyeloperoxidase [49].…”

“…Serological demonstration of these ANCAs is a sensitive and specific means by which to diagnose WG, provided a positive result on a screening leukocyte indirect immunofluorescence microscopic ANCA study is followed up by enzyme linked immunoabsorbent assay demonstration of antiproteinase 3 and antimyeloperoxidase [49].…”