Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

Åberg, Maria; Åberg, N. David; Hedbäcker, H; Oscarsson, Jan; Eriksson, Peter S.

doi:10.1523/jneurosci.20-08-02896.2000

Cited by 766 publications

(517 citation statements)

References 71 publications

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“…It is possible that the muscarinic signaling cascade may be part of, and/ or play a synergistic role to, the cytokine system, whose role in neurogenesis has been suggested by other investigators. [11][12][13][14][15] Whether neurogenesis was causative of biochemical recovery, most importantly of PKC, or merely parallel thereof, remains a subject of future investigation.…”

Section: Discussionmentioning

confidence: 99%

“…One possibility is the induction of cytokines by neural progenitors, [8][9][10] which enhance proliferation of endogenous neural cells. [11][12][13][14][15] Here, we aimed to examine our hypothesis by employing the prenatally heroin-damaged brain model. The heroin model was chosen because, among other effects, it induces deficits that can be related to specific synaptic functions.…”

Section: Introductionmentioning

confidence: 99%

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Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain

2007

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Grafting of neural progenitors has been shown to reverse a wide variety of neurobehavioral defects. While their role of replacing injured cells and restoring damaged circuitries has been shown, it is widely accepted that this cannot be the only mechanism, as therapy can occur even when an insufficient number of transplanted cells are found. We hypothesized that one major mechanism by which transplanted neural progenitors exert their therapeutic effect is by enhancing endogenous cells production. Consequently, in an allographic model of transplantation, prenatally heroin-exposed genetically heterogeneous (HS) mice were made defective in their hippocampal neurobehavioral function by exposing their mothers to heroin (10 mg kg À1 heroin on gestation days 9-18). Hippocampal damage was confirmed by deficient performance in the Morris maze (P < 0.009), and decreased production of endogenous cells in the dentate gyrus by 39% was observed. On postnatal day 35, they received an HS-derived neural progenitors transplant followed by repeated bromodeoxyuridine injections. The transplant returned endogenous cells production to normal levels (P < 0.006) and reversed the behavioral defects (P < 0.03), despite the fact that only 0.0334% of the transplanted neural progenitors survived and that they differentiated mainly to astrocytes. An immunological study demonstrated the presence of macrophages and T cells as a possible explanation for the paucity of the transplanted cells. This study suggests one mechanism for the therapeutic action of neural progenitors, the enhancement of the production of endogenous cells, pointing to future clinical applications in this direction by use of neural progenitors or by analogous cell-inducing techniques.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain

2007

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“…A second approach using electrophysiology to measure from GFP-retrovirally labeled cells showed that integrated neurons exhibited neuronal morphology and displayed passive membrane properties and action potentials (Song et al, 2002;van Praag et al, 2002). Furthermore, neurogenesis in the hippocampus can be induced by exogenous factors, including peripheral administration of insulin-like growth factor-I (IGF-I) (Aberg et al, 2000) or hormones like corticosteroids (Tanapat et al, 1999;Gass et al, 2000), enriched environment (Kempermann et al, 1997;Nilsson et al, 1999), exercise (van Praag et al, 1999a,b;Gould et al, 2000), or interestingly, by hypoxia (Liu et al, 1998). Unfortunately, none of these reports has demonstrated that these signals can be used as strategies for regeneration in humans.…”

Section: Physiological Function and Regulation Of Cns Stem Cellsmentioning

confidence: 99%

Mechanism of stem cells in the central nervous system

Johansson

2003

Journal Cellular Physiology

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Injury to the central nervous system (CNS) can result in severe functional impairment. The brain and spinal cord, which constitute the CNS, have been viewed for decades as having a very limited capacity for regeneration. However, over the last several years, the body of evidence supporting the concept of regeneration and continuous renewal of neurons in specific regions of the CNS has increased. This evidence has significantly altered our perception of the CNS and has offered new hope for possible cell therapy strategies to repair lost function. Transplantation of stem cells or the recruitment of endogenous stem cells to repair specific regions of the brain or spinal cord is the next exciting research challenge. However, our understanding of the existing stem cell pool in the adult CNS remains limited. This review will discuss the identification and characterization of CNS stem cells in the adult brain and spinal cord.

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“…61 Selective induction of neurogenesis has also been achieved using IGF-1. 62,63 Further studies should elucidate the possible involvement of these molecules in the mechanism of action of tianeptine and other antidepressants.…”

Section: Neurobiological Properties Of Tianeptinementioning

confidence: 99%

Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine

McEwen

Olie

2005

Mol Psychiatry

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Recent studies have provided evidence that structural remodeling of certain brain regions is a feature of depressive illness, and the postulated underlying mechanisms contribute to the idea that there is more to antidepressant actions that can be explained exclusively by a monoaminergic hypothesis. This review summarizes recent neurobiological studies on the antidepressant, tianeptine (S-1574, [3-chloro-6-methyl-5,5-dioxo-6,11-dihydro-(c,f)-dibenzo-(1,2-thiazepine)-11-yl) amino]-7 heptanoic acid, sodium salt), a compound with structural similarities to the tricyclic antidepressant agents, the efficacy and good tolerance of which have been clearly established. These studies have revealed that the neurobiological properties of tianeptine involve the dynamic interplay between numerous neurotransmitter systems, as well as a critical role of structural and functional plasticity in the brain regions that permit the full expression of emotional learning. Although the story is far from complete, the schema underlying the effect of tianeptine on central plasticity is the most thoroughly studied of any antidepressants. Effects of tianeptine on neuronal excitability, neuroprotection, anxiety, and memory have also been found. Together with clinical data on the efficacy of tianeptine as an antidepressant, these actions offer insights into how compounds like tianeptine may be useful in the treatment of neurobiological features of depressive disorders. Molecular Psychiatry (2005) 10, 525-537.

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Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

Cited by 766 publications

References 71 publications

Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain

Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain

Mechanism of stem cells in the central nervous system

Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine

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