Peripheral chemokine levels in women with recurrent major depression with suicidal ideation

Reduced serum levels of adiponectin in tension-type headache

“…The percentage of obese patients was not significantly different between patients and controls, as well as between patients with episodic and chronic TTH. Altered levels of ADP have also been reported in neuropsychiatric disorders including depression and anxiety [23][24][25]. In the present study, patients with TTH had higher depression and anxiety scores than controls; however, the difference of ADP levels between patients and controls remained after adjusting for BDI and BAI scores, suggesting that the reduced ADP levels in TTH were not secondary or associated with depression or anxiety symptoms.…”

Comparison of chemokines (CCL-5 and SDF-1), chemokine receptors (CCR-5 and CXCR-4) and IL-6 levels in patients with different severities of depression

“…Very few studies on the role of the immune system in the development of depression have shown chemokine involvement in this process [23,24]. Moreover, it seems that RANTES and SDF-1 chemokines and their corresponding receptors may play a significant role in depression.…”

Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients

“…However, one study (15) was available that analyzed chemokine differences between psychiatric patients and healthy control subjects for MCP-1/CCL-2, RANTES/CCL-5, and eotaxin/CCL-11. The chemokines MCP-1/CCL-2 and RANTES/CCL-5 were significantly lower in suicidal patients versus control subjects (p , .001), whereas eotaxin/CCL-11 was significantly higher (p 5 .04) in suicidal patients (15). …”

“…Sensitivity analysis was not possible because of the small number of studies. When assessing single studies, regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL-5 (p , .001)(15) and thymus and activation-regulated chemokine (TARC)/CCL-17 (p , .05)(20) were both significantly lower in suicidal patients versus nonsuicidal patients. Results for macrophage inflammatory protein (MIP)-1β/CCL-4, MCP-4/ CCL-13, and interferon-γ-induced protein (IP)-10/C-X-C motif ligand (CXCL)-10 were not significant(20).…”