Peripheral blood stem cells collection on spectra optia apheresis system using the continuous mononuclear cell collection protocol: A single center report of 39 procedures

Sanderson, F.; Poullin, Pascale; Smith, Richard J.; Nicolino-Brunet, Corinne; Philip, P.; Chaïb, Aurès; Costello, Régis

doi:10.1002/jca.21485

Cited by 24 publications

(42 citation statements)

References 13 publications

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“…However, no bleeding was observed as a direct result of the decreased platelet count and no transfusion support was required. Indeed, the platelet loss observed in adult patients was similar in magnitude to that previously reported with non‐LVL using the Spectra Optia CMNC protocol by Sanderson et al…”

Section: Discussionsupporting

confidence: 87%

“…Here we assessed the processing of larger blood volumes using the new continuous mononuclear cell collection (CMNC) protocol on the Spectra Optia apheresis system (Terumo BCT, USA). While the feasibility and efficiency of stem cell collection using Spectra Optia CMNC has been reported previously, this is the first study on LVL performance in pediatric patients assessing side effects, anticoagulant choice and specialized procedures such as adequate venous access and extracorporeal volume . In addition, CD34+ cell yield predictability, determined using a customized algorithm to estimate the blood processing volume required based on circulating CD34+ count and linear regression variables, was assessed.…”

Section: Introductionmentioning

confidence: 99%

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Performance prediction algorithm for autologous PBSC collection in adults and pediatric patients using large volume leukapheresis

Bojanić

Besson

Vidović

et al. 2019

J of Clinical Apheresis

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Background and Objectives The number of CD34+ cells collected in apheresis procedures depends mainly on the collection efficiency of the device and the blood volume processed. Large volume leukapheresis (LVL) can improve CD34+ cell yield and has previously been investigated using the COBE Spectra device (Terumo BCT, USA). Materials and Methods This was a retrospective analysis of LVL performance in patients undergoing continuous mononuclear cell collection (CMNC) using the new Spectra Optia apheresis system (Terumo BCT, USA) at the University Hospital Center, Zagreb, from March 2016 to September 2016. CD34+ cell yield predictability, determined using a customized algorithm, was also assessed. Results In total, 67 procedures performed in 46 adults and 14 performed in 11 children were included in the analysis. In adults, 30 (65.2%) patients successfully reached their target preapheresis CD34+ cell count on day 1, with a median (interquartile range [IQR]) CD34+ collected cell dose of 4.8 × 106/kg (2.3‐10.6 × 106/kg). In the pediatric group, 81.8% successfully collected the target CD34+ cell dose on the first day, with a median (IQR) CD34+ collected cell dose of 11.1 × 106/kg (3.2‐16.3 × 106/kg). The customized algorithm showed a strong and significant linear correlation with actual CD34+ cell dose (P < 0.0001). Conclusion The results of this study support the use of LVL and the customized prediction algorithm in apheresis procedures. The ability to tailor the procedure to meet the needs of the individual patient may help to minimize the blood volume processed, shorten the duration, reduce the volume of infused anticoagulants, and improve patient comfort.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Performance prediction algorithm for autologous PBSC collection in adults and pediatric patients using large volume leukapheresis

Bojanić

Besson

Vidović

et al. 2019

J of Clinical Apheresis

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“…The results are comparable to published data in adults. Cancelas et al reported a 62% CE2 in healthy adult donors, Sanderson et al reported a CE2 of 48.5% in adult myeloma and lymphoma patients . A direct comparison of MNC and CMNS in adults has been published by Lisenko et al who reported in a retrospective analysis a CE2 of 39% to 50% in 72 patients with malignancies, which was not significantly different from the studied MNC group .…”

Section: Discussionmentioning

confidence: 83%

Comparison between intermittent and continuous leukapheresis protocols for autologous hematopoietic stem cell collections in children

Ali

Chiang

Even‐Or

et al. 2019

J of Clinical Apheresis

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Background Peripheral hematopoietic stem cell (HSC) collections are needed for autologous hematopoietic stem cell transplantation (HSCT). Since 2015, our institution has utilized a secondary chamber mononuclear cell (MNC) protocol on the Spectra Optia apheresis system. Recently, a new continuous mononuclear collection protocol (CMNC) was developed for the same device. As there is limited data available regarding the use of the CMNC protocol in children, we compared collection efficiency (CE2), side effects, and clinical feasibility between the two protocols in patients <18 years old. Study Design and Methods We prospectively collected clinical, laboratory, and technical collection data from HSC collection procedures performed with the Spectra Optia apheresis system utilizing the CMNC protocol. Data were compared to retrospectively collected data utilizing the MNC protocol. Data collection included donor demographics, precollection peripheral CD34+ cell counts, total CD34+ cells collected, collection efficiency, side effects, and collection product characteristics. Results A total of 96 HSC collection procedures were performed on 79 pediatric patients utilizing either the MNC (61 patients) or CMNC (18 patients) protocol. The collection efficiencies were comparable between MNC and CMNC cohorts (52.9% vs 54.9%, P = 0.711). Platelet loss was significantly lower in the CMNC cohort (P = 0.002), especially in children weighing <15 kg. Product volumes were higher with CMNC. No significant collection‐related side effects were noted with either protocol. Conclusions MNC and CMNC protocols have comparable collection efficiencies and are both feasible and safe for the use in children. Centers may choose between the methods depending on clinical needs.

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“…Thus, it would be convenient for both the donors and the transplantation coordinating facilities to know when the collection can be completed so they can arrange transportation, etc. Moreover, although PBSC collection is generally a safe, well tolerated procedure [10], procedure related adverse events still occurs [11] and the length of PBSC collection has been associated with more adverse events and bad donation experience [12,13]. Therefore, it is desirable to have a reliable prediction method in order to avoid unnecessarily prolonged collection for the safety of donors.…”

Section: Introductionmentioning

confidence: 99%

A Method to Predict the Yield of Peripheral Blood Stem Cells Collected by Large Volume Leukapheresis

J¹,

Burns²,

Kennedy³

et al. 2017

J Blood Lymph

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Background: Collection of peripheral blood stem cells (PBSC) by leukapheresis has become the dominant method in allogeneic hematopoietic stem cell donation and also overpassed bone marrow donation in autologous transplantations. The circulating CD34 positive cells immediately prior to PBSC collection strongly correlate with the PBSC yield and have used to monitor donor's response to bone marrow mobilization. Methods:In this prospective study, a prediction method for PBSC collection that has been used in our facility was provided. Prediction accuracy is evaluated by comparison of predicted CD34 values to real PBSC yield. Results:The prediction method was used to determine first if a standard procedure with 12 L of blood processing could achieve the collection goal. Thirty seven donors were considered to have adequate PBSCs. Thirty four of them had a CD34 count above the target and only one donor had a CD34 count significantly below the target. For the donors whose PBSC were considered inadequate, an extended collection was performed based on the predicted blood volume that needed to be processed. The number of overestimated predictions was essentially the same as the number of underestimated predictions. Conclusion:The proposed prediction method was successful in identifying donors who needed extended collection without causing unnecessary prolongation of the leukapheresis procedure.

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Peripheral blood stem cells collection on spectra optia apheresis system using the continuous mononuclear cell collection protocol: A single center report of 39 procedures

Cited by 24 publications

References 13 publications

Performance prediction algorithm for autologous PBSC collection in adults and pediatric patients using large volume leukapheresis

Performance prediction algorithm for autologous PBSC collection in adults and pediatric patients using large volume leukapheresis

Comparison between intermittent and continuous leukapheresis protocols for autologous hematopoietic stem cell collections in children

A Method to Predict the Yield of Peripheral Blood Stem Cells Collected by Large Volume Leukapheresis

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