Peripheral blood leptin and resistin levels as clinical activity biomarkers in Mexican Rheumatoid Arthritis patients

Rivera-Bahena, Carolina Bustos; Xibillé-Friedmann, Daniel-Xavier; González-Christen, Judith; Carrillo-Vázquez, Sandra; Montiel-Hernández, José Luis

doi:10.1016/j.reuma.2015.11.011

Cited by 27 publications

(20 citation statements)

References 14 publications

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“…The most recent study on this topic demonstrated that circulating Leptin, Resistin, IL-6 and IL-17 levels positively correlated with the clinical activity of RA patients in a BMI-independent way and, while Resistin showed a limited correlation with other inflammatory cytokines, Leptin showed a positive association with IL-1b [35].…”

Section: Energy Intake Body Mass Index (Bmi) Body Composition Physical Activity and Rheumatoid Arthritismentioning

confidence: 99%

Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with chronic obstructive pulmonary disease

et al. 2021

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Section: Energy Intake Body Mass Index (Bmi) Body Composition Physical Activity and Rheumatoid Arthritismentioning

confidence: 99%

Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with chronic obstructive pulmonary disease

et al. 2021

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“…Although most studies describe no differences between serum or plasma resistin levels in RA patients and controls [71,113,128,156,158], other authors have reported higher resistin serum levels in RA when compared with healthy controls or with OA patients [155,159]. There is evidence that resistin serum levels in RA patients are positively correlated with inflammatory markers, such as erythrocyte sedimentation rate (ESR) and CRP levels, as well as with the degree of disease activity measured by DAS28 [113,155,160]. Another study also demonstrated a positive correlation between circulating levels of this adipokine and TNF-α levels in blood from RA patients [161], whereas no relationship with TNF-α, CRP levels, leukocytes counts, or with other pro-inflammatory cytokines such as IL6, IL8, or MCP-1 was found by other authors [128,155].…”

Section: Resistinmentioning

confidence: 99%

The Adipokine Network in Rheumatic Joint Diseases

Carrión

Frommer

Pérez‐García

et al. 2019

IJMS

134

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Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common, leading to considerable functional limitations and irreversible disability when patients are unsuccessfully treated. Although the specific causes of many rheumatic conditions remain unknown, it is generally accepted that immune mechanisms and/or uncontrolled inflammatory responses are involved in their etiology and symptomatology. In this regard, the bidirectional communication between neuroendocrine and immune system has been demonstrated to provide a homeostatic network that is involved in several pathological conditions. Adipokines represent a wide variety of bioactive, immune and inflammatory mediators mainly released by adipocytes that act as signal molecules in the neuroendocrine-immune interactions. Adipokines can also be synthesized by synoviocytes, osteoclasts, osteoblasts, chondrocytes and inflammatory cells in the joint microenvironment, showing potent modulatory properties on different effector cells in OA and RA pathogenesis. Effects of adiponectin, leptin, resistin and visfatin on local and systemic inflammation are broadly described. However, more recently, other adipokines, such as progranulin, chemerin, lipocalin-2, vaspin, omentin-1 and nesfatin, have been recognized to display immunomodulatory actions in rheumatic diseases. This review highlights the latest relevant findings on the role of the adipokine network in the pathophysiology of OA and RA.

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“…Moreover, the researchers found a correlation between release of resistin from cultured OA cartilage and resistin levels in synovial fluid. Similarly, one study has reported that levels of circulating leptin resistin, IL-6 and IL-17, were positively correlated with clinical disease activity in Mexican patients with RA [82].…”

Section: Resistin In Arthritismentioning

confidence: 99%

Associations between Adipokines in Arthritic Disease and Implications for Obesity

MacDonald

Liu

Huang

et al. 2019

IJMS

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Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in inflammatory arthritis and obesity. This review considers the evidence generated over the last decade regarding the effects of several adipokines including leptin, adiponectin, visfatin, resistin, chemerin and apelin, in cartilage and bone homeostasis in the pathogenesis of rheumatoid arthritis and osteoarthritis, which has important implications for obesity.

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Peripheral blood leptin and resistin levels as clinical activity biomarkers in Mexican Rheumatoid Arthritis patients

Cited by 27 publications

References 14 publications

Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with chronic obstructive pulmonary disease

Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with chronic obstructive pulmonary disease

The Adipokine Network in Rheumatic Joint Diseases

Associations between Adipokines in Arthritic Disease and Implications for Obesity

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