volume 93, issue 0, P3-O-080 2020
DOI: 10.1254/jpssuppl.93.0_3-o-080
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Abstract: Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ. Periostin (POSTN), a matricellular protein is related to structural remodeling of pathological heart. However, it remains to be clarified whether POSTN mediates electrical disorders of heart. Thus, we investigated the effects of POSTN on electrophysiological properties in rat ventricular myocytes. Male Wistar rats were injected with recombinant rat POSTN (64 mg/kg, i.v.) for 24 h. After electrocardiogram was recorded, ventricular myocytes were isolated. Ac…

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