Periorbital and Ocular Necrobiotic Xanthogranuloma Leading to Perforation

Abstract

We thank all the patients, their families, and the controls who participated in the study. 1. Yang Z, Camp NJ, Sun H, et al. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.

Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma

“…Lagophthalmos as a result of periocular involvement can result in exposure keratopathy with subsequent perforation, endophthalmitis, and loss of the eye. 78 In our patient, lagophthalmos and poor blink reflex in the right eye have led to exposure keratitis requiring frequent lubrication. Exposure keratopathy puts this patient at risk for infectious keratitis.…”

Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma

“…Lagophthalmos as a result of periocular involvement can result in exposure keratopathy with subsequent perforation, endophthalmitis, and loss of the eye. 78 In our patient, lagophthalmos and poor blink reflex in the right eye have led to exposure keratitis requiring frequent lubrication. Exposure keratopathy puts this patient at risk for infectious keratitis.…”

Treatment of necrobiotic xanthogranuloma – a systematic review

“…A recent report showed some success when used alone in treatment of isolated NXG, but it was discontinued due to pancytopenia . Another report showed significant improvement of cutaneous disease, when used as adjuvant therapy with hyperbaric oxygen and surgery, in a patient with NXG and underlying multiple myeloma resistant to lenalidomide and dexamethasone treatment …”

A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria

“…In the systematic review, the initial search yielded 1199 records, 151 of which were included (Figure). These reports described 201 patients with NXG, with demographics, comorbidities, and clinical features (detailed in the eTable in the Supplement).…”

Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma

“…Lagophthalmos as a result of periocular involvement can result in exposure keratopathy with subsequent perforation, endophthalmitis, and loss of the eye. 78 In our patient, lagophthalmos and poor blink reflex in the right eye have led to exposure keratitis requiring frequent lubrication. Exposure keratopathy puts this patient at risk for infectious keratitis.…”

Treatment of necrobiotic xanthogranuloma – a systematic review

“…A recent report showed some success when used alone in treatment of isolated NXG, but it was discontinued due to pancytopenia . Another report showed significant improvement of cutaneous disease, when used as adjuvant therapy with hyperbaric oxygen and surgery, in a patient with NXG and underlying multiple myeloma resistant to lenalidomide and dexamethasone treatment …”

A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria

“…In the systematic review, the initial search yielded 1199 records, 151 of which were included (Figure). These reports described 201 patients with NXG, with demographics, comorbidities, and clinical features (detailed in the eTable in the Supplement).…”

Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma

“…Lagophthalmos as a result of periocular involvement can result in exposure keratopathy with subsequent perforation, endophthalmitis, and loss of the eye. 78 In our patient, lagophthalmos and poor blink reflex in the right eye have led to exposure keratitis requiring frequent lubrication. Exposure keratopathy puts this patient at risk for infectious keratitis.…”

Treatment of necrobiotic xanthogranuloma – a systematic review

“…A recent report showed some success when used alone in treatment of isolated NXG, but it was discontinued due to pancytopenia . Another report showed significant improvement of cutaneous disease, when used as adjuvant therapy with hyperbaric oxygen and surgery, in a patient with NXG and underlying multiple myeloma resistant to lenalidomide and dexamethasone treatment …”

A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria

“…In the systematic review, the initial search yielded 1199 records, 151 of which were included (Figure). These reports described 201 patients with NXG, with demographics, comorbidities, and clinical features (detailed in the eTable in the Supplement).…”