Perioperative synbiotics administration decreases postoperative infections in patients with colorectal cancer: a randomized, double-blind clinical trial

Flesch, A.; Tonial, Stael T; Contu, Paulo de Carvalho; Damin, Daniel C.

doi:10.1590/0100-69912017006004

Cited by 55 publications

(42 citation statements)

References 22 publications

(15 reference statements)

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“…A surgical site infection occurred in 2% of the patients receiving the synbiotic product and 21.4% of the participants consuming placebo ( p = .002). 62 As Kuugbee et al . reported, the administration to rats of a cocktail consisting of oligofructose-maltodextrin-enriched Lactobacillus acidophilus (6,4 x 10 11 CFU), Bifidobacteria bifidum, Bifidobacteria infantum (1,9 x 10 10 CFU) increased the expression of MUC2, ZO-1, occludin, and TRL2.…”

Section: Modification Of Gut Microbiota In Crc – Therapeutic Methodsmentioning

confidence: 98%

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Kaźmierczak-Siedlecka

Daca

Fic

et al. 2020

Gut Microbes

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The link between gut microbiota and the development of colorectal cancer has been investigated. An imbalance in the gut microbiota promotes the progress of colorectal carcinogenesis via multiple mechanisms, including inflammation, activation of carcinogens, and tumorigenic pathways as well as damaging host DNA. Several therapeutic methods are available with which to alter the composition and the activity of gut microbiota, such as administration of prebiotics, probiotics, and synbiotics; these can confer various benefits for colorectal cancer patients. Nowadays, fecal microbiota transplantation is the most modern way of modulating the gut microbiota. Even though data regarding fecal microbiota transplantation in colorectal cancer patients are still rather limited, it has been approved as a clinical method of treatment-recurrent Clostridium difficile infection, which may also occur in these patients. The major benefits of fecal microbiota transplantation include modulation of immunotherapy efficacy, amelioration of bile acid metabolism, and restoration of intestinal microbial diversity. Nonetheless, more studies are needed to assess the long-term effects of fecal microbiota transplantation. In this review, the impact of gut microbiota on the efficiency of anti-cancer therapy and colorectal cancer patients' overall survival is also discussed.

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Section: Modification Of Gut Microbiota In Crc – Therapeutic Methodsmentioning

confidence: 98%

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Kaźmierczak-Siedlecka

Daca

Fic

et al. 2020

Gut Microbes

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show abstract

“…Moreover, according to the result of a trial published in 2017, the randomized administration of Bifidobacterium lactis and Lactobacillus acidophilus to CRC patients, can change the epigenetic patterns of tumor tissue from its baseline, with potential therapeutic benefits in CRC by manipulation of the gut microbiota [100]. The same year a randomized clinical trial with CRC patients demonstrated that the perioperative administration of a mixture of prebiotics and probiotics, significantly reduced postoperative infection rates in patients with CRC [101].…”

Section: Gut Microbiota and Anti-cancer Therapymentioning

confidence: 99%

Gut Microbiota and Cancer: From Pathogenesis to Therapy

Vivarelli

Salemi

Candido

et al. 2019

Cancers

400

278

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Cancer is a multifactorial pathology and it represents the second leading cause of death worldwide. In the recent years, numerous studies highlighted the dual role of the gut microbiota in preserving host’s health. Gut resident bacteria are able to produce a number of metabolites and bioproducts necessary to protect host’s and gut’s homeostasis. Conversely, several microbiota subpopulations may expand during pathological dysbiosis and therefore produce high levels of toxins capable, in turn, to trigger both inflammation and tumorigenesis. Importantly, gut microbiota can interact with the host either modulating directly the gut epithelium or the immune system. Numerous gut populating bacteria, called probiotics, have been identified as protective against the genesis of tumors. Given their capability of preserving gut homeostasis, probiotics are currently tested to help to fight dysbiosis in cancer patients subjected to chemotherapy and radiotherapy. Most recently, three independent studies show that specific gut resident species may potentiate the positive outcome of anti-cancer immunotherapy. The highly significant studies, uncovering the tight association between gut microbiota and tumorigenesis, as well as gut microbiota and anti-cancer therapy, are here described. The role of the Lactobacillus rhamnosus GG (LGG), as the most studied probiotic model in cancer, is also reported. Overall, according to the findings here summarized, novel strategies integrating probiotics, such as LGG, with conventional anti-cancer therapies are strongly encouraged.

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“…Numerous clinical trials have been conducted to investigate the effects of probiotics/prebiotics on cancer. Some trials [100][101][102][103] reported an improved clinical outcome of patients receiving probiotics, whereas others 104 105 failed to examine a significant effect induced by probiotics (online supplementary S table 1).…”

Section: Bacteria Compositional Modulation By Probiotics In Cancermentioning

confidence: 99%

The role of gut microbiota in cancer treatment: friend or foe?

Cheng

2020

Gut

198

110

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The gut microbiota has been implicated in cancer and shown to modulate anticancer drug efficacy. Altered gut microbiota is associated with resistance to chemo drugs or immune checkpoint inhibitors (ICIs), whereas supplementation of distinct bacterial species restores responses to the anticancer drugs. Accumulating evidence has revealed the potential of modulating the gut microbiota to enhance the efficacy of anticancer drugs. Regardless of the valuable findings by preclinical models and clinical data of patients with cancer, a more thorough understanding of the interactions of the microbiota with cancer therapy helps researchers identify novel strategy for cancer prevention, stratify patients for more effective treatment and reduce treatment complication. In this review, we discuss the scientific evidence on the role of gut microbiota in cancer treatment, and highlight the latest knowledge and technologies leveraged to target specific bacteria that contribute to tumourigenesis. First, we provide an overview of the role of the gut microbiota in cancer, establishing the links between bacteria, inflammation and cancer treatment. Second, we highlight the mechanisms used by distinct bacterial species to modulate cancer growth, immune responses, as well as the efficacy of chemotherapeutic drugs and ICIs. Third, we demonstrate various approaches to modulate the gut microbiota and their potential in translational research. Finally, we discuss the limitations of current microbiome research in the context of cancer treatment, ongoing efforts to overcome these challenges and future perspectives.

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Perioperative synbiotics administration decreases postoperative infections in patients with colorectal cancer: a randomized, double-blind clinical trial

Abstract: A administração perioperatória de simbióticos em pacientes com câncer colorretal reduz a incidência de infecções pós-operatórias: ensaio clínico randomizado duplo-cego

Cited by 55 publications

References 22 publications

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Gut Microbiota and Cancer: From Pathogenesis to Therapy

The role of gut microbiota in cancer treatment: friend or foe?

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