2017
DOI: 10.1016/j.bjane.2016.07.014
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Perioperative gabapentin and pregabalin in cardiac surgery: a systematic review and meta-analysis

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Cited by 18 publications
(15 citation statements)
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“…22,23 Previous systematic reviews have weaknesses. First, most were designed to look at specific surgical populations [24][25][26][27][28][29][30][31][32][33] with often a limited sampling frame or a specific type of drugs [34][35][36][37][38][39][40] when pregabalin and gabapentin share the same mechanism of action and comparable pharmacologic properties. 41,42 Second, the concept of minimally important difference 43 for pain intensity was never considered in previous work, neither was the statistical reliability of the findings quantified.…”
Section: Perioperative Medicinementioning
confidence: 99%
“…22,23 Previous systematic reviews have weaknesses. First, most were designed to look at specific surgical populations [24][25][26][27][28][29][30][31][32][33] with often a limited sampling frame or a specific type of drugs [34][35][36][37][38][39][40] when pregabalin and gabapentin share the same mechanism of action and comparable pharmacologic properties. 41,42 Second, the concept of minimally important difference 43 for pain intensity was never considered in previous work, neither was the statistical reliability of the findings quantified.…”
Section: Perioperative Medicinementioning
confidence: 99%
“…The selected interventions introduced in this study are borne from existing literature that supports their use as measures to hasten recovery from anesthesia, optimize multimodal analgesia, and limit the harmful impact of mechanical ventilation. They include preventative multimodal acetaminophen, gabapentin, intraoperative ketamine infusions, and regional analgesia, which have been shown to reduce perioperative opioid administration in cardiac and other types of surgery, [20][21][22][23][24][25][26] and therefore may reduce the impact of the anesthetic on rates of recovery. We incorporated a lung protective mechanical ventilation strategy, evidenced to reduce rates of postoperative lung injury and pneumonia.…”
Section: Discussionmentioning
confidence: 99%
“…57,58 A recently published systematic review of 281 studies (all surgical procedures) investigating the role of gabapentinoids for acute postoperative pain showed minimal analgesic benefit and increased incidence of visual disturbances and dizziness. 59 Another systematic review of the above studies by Maitra et al 60 found that gabapentin did not reduce postoperative opioid consumption after cardiac surgery. However, it might have reduced pain scores at the expense of increased duration of mechanical ventilation.…”
Section: Gabapentinmentioning
confidence: 99%