Periodontitis and concentrations of the cellular immune activation marker neopterin in saliva and urine

Vrecko, Karoline; Staedtler, Peter; Mischak, Irene; Maresch, Laurenz; Reibnegger, Gilbert

doi:10.1016/s0009-8981(97)00154-x

Cited by 34 publications

(34 citation statements)

References 18 publications

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“…IFN-␥ released by activated T lymphocytes type 1 is the most potent inducer of NP production, and the concentration of NP indicates the presence of IFN-␥ in body fluids [8] . Because IFN-␥ is released by active T cells, NP may be a sensitive marker of cell-mediated immunity [8,9] . NP concentrations rise in the early stage of different diseases and increased levels usually correlate with the severity of the disease [11] .…”

Section: Discussionmentioning

confidence: 99%

Role of Neopterin, C-Reactive Protein and Myeloperoxidase in Patients Undergoing Cardiopulmonary Bypass

Ayaz¹,

Ünlü

Sucu³

et al. 2010

Med Princ Pract

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Objective: The aim of the present study was to investigate the role of neopterin (NP), C-reactive protein (CRP) and myeloperoxidase (MPO) in patients undergoing coronary artery bypass grafting with or without cardiopulmonary bypass (CPB). Patients and Methods: Forty patients submitted for elective coronary artery bypass grafting were included in this prospective study. Patients were divided into two groups of 20 individuals, those who did not undergo CPB (group 1), aged 54.1 ± 13.5 years, and those who did (group 2), aged 60.2 ± 11.7 years. In group 1, there were 17 males and 3 females, while in group 2, there were 16 males and 4 females. Serum CRP, serum and urine NP and leukocyte MPO activity were measured preoperatively, at the end of surgery, and 4, 24 and 72 h after surgery using high-performance liquid chromatography, immunoturbidimetry and the reduction in o-dianizidine, respectively. Results: The level of serum NP was higher preoperatively and at the end of surgery (0 h), 4, 24, and 72 h after the operation in those who underwent CPB compared to those who did not. However, there was no significant difference in NP concentrations between the two groups at any time except 24 h after surgery (p = 0.002). Urine NP concentrations showed similar values preoperatively but increased postoperatively in both groups of patients. The only significant difference in urine NP concentration between the two groups occurred at 0 and 24 h after surgery (p = 0.001, p = 0.000). Serum CRP concentrations showed similar values preoperatively, at the end of surgery and 72 h after the operation and increased at 4 and 24 h postoperatively in both groups. The only significant difference in CRP concentration between the two groups occurred 4 and 24 h after surgery (p = 0.024 and p = 0.000, respectively). MPO levels were found to be increased in the CPB patients when compared to those patients who did not undergo CPB. However, the difference between the groups was not statistically significant. Conclusion: Our data show that CPB induced a rise in NP and CRP levels.

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Section: Discussionmentioning

confidence: 99%

Role of Neopterin, C-Reactive Protein and Myeloperoxidase in Patients Undergoing Cardiopulmonary Bypass

Ayaz¹,

Ünlü

Sucu³

et al. 2010

Med Princ Pract

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“…It has been demonstrated that salivary neopterin concentrations decrease after the resection of tumor in oral cavity. However, an association of salivary neopterin with periodontal infection complicates the interpretation of neopterin concentrations in saliva (100,101). High cerebrospinal fluid neopterin concentrations have been reported in patients with acute lymphoblastic leukemia or lymphoma involving the central nervous system (98,102).…”

Section: Neopterin As Biomarker In the Tumor Microenvironmentmentioning

confidence: 99%

Neopterin as a biomarker of immune response in cancer patients

Melichar¹,

Spisarová²,

Bartoušková³

et al. 2017

Ann. Transl. Med.

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“…Neopterin is formed by hydrolysis and oxidation of 7,8-dihydroneopterin triphosphate, which originates from the conversion of guanosine triphosphate by the action of guanosine triphosphate-cyclohydrolase I (2)(3)(4). The amount of neopterin secreted is strongly related to the release of reactive oxygen radicals by cells, reflecting the level of oxidative stress caused by activation of the immune system (5 ).…”

confidence: 99%

Neopterin as a Predictor of Total and Cardiovascular Mortality in Individuals Undergoing Angiography in the Ludwigshafen Risk and Cardiovascular Health Study

et al. 2009

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Background: Neopterin is produced upon activation of the cell-mediated immune response, and may be a novel risk marker for adverse outcomes resulting from coronary artery disease. Methods: We measured neopterin in 1801 study participants with and 511 without angiographic coronary artery disease. Rates of death were determined after a median follow-up of 8.0 years. Results: Estimated glomerular filtration rate and N-terminal pro-B–type natriuretic peptide (NT-proBNP) were the strongest predictors of neopterin. Neopterin was positively related to age and inversely related to LDL cholesterol, HDL cholesterol, and triglycerides. Use of lipid-lowering drugs lowered neopterin. Sex, body mass index, diabetes mellitus, hypertension, smoking status, Friesinger coronary score, and clinical instability at presentation were not associated with neopterin. Unlike C-reactive protein, neopterin was not increased in unstable angina pectoris, non–ST–elevation myocardial infarction, or ST-elevation myocardial infarction. In the third and fourth quartiles of neopterin, unadjusted hazard ratios for death from any cause were 1.94 (95% CI 1.44–2.61) and 3.32 (95% CI 2.53–4.30) compared to individuals in the first quartile, whereas hazard ratios for death from cardiovascular causes were 2.14 (95% CI 1.44–3.18) and 3.84 (95% CI 2.67–5.52), respectively. Neopterin remained predictive of total and cardiovascular mortality after adjusting for sex, age, body mass index, type 2 diabetes, hypertension, smoking status, LDL cholesterol, HDL cholesterol, triglycerides, estimated glomerular filtration rate, NT-proBNP, and clinical status at presentation, but NT-proBNP substantially weakened this association. Conclusions: Neopterin is an independent predictor of all-cause and cardiovascular mortality in individuals with or without stable coronary artery disease.

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Periodontitis and concentrations of the cellular immune activation marker neopterin in saliva and urine

Cited by 34 publications

References 18 publications

Role of Neopterin, C-Reactive Protein and Myeloperoxidase in Patients Undergoing Cardiopulmonary Bypass

Role of Neopterin, C-Reactive Protein and Myeloperoxidase in Patients Undergoing Cardiopulmonary Bypass

Neopterin as a biomarker of immune response in cancer patients

Neopterin as a Predictor of Total and Cardiovascular Mortality in Individuals Undergoing Angiography in the Ludwigshafen Risk and Cardiovascular Health Study

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