Periodontitis and Buerger's Disease: Recent Advances

Pavlić, Verica; Vujić-Aleksić, Vesna; Zubović, Nina; Gojkov-Vukelić, Mirjana

doi:10.5455/aim.2013.21.250-252

Cited by 14 publications

(7 citation statements)

References 26 publications

(39 reference statements)

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“…Many patients will have more than one limb involved, and a positive Allen's test may be found on physical examination [3] . Almost two-thirds of Buerger patients have periodontal disease [6] . In addition, Raynaud's phenomenon and superficial thrombophlebitis are present in 40% of patients.…”

Section: Discussionmentioning

confidence: 99%

Thromboangiitis obliterans (Buerger disease)

Seebald

Gritters

2015

Radiology Case Reports

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Thromboangiitis obliterans (Buerger disease) is an occlusive, nonatherosclerotic, inflammatory vasculitis that causes ischemia in small and medium vessels. Most commonly, Buerger disease is diagnosed in 40- to 45-year-old men with a heavy smoking history. Our case exemplifies the most common presentation, diagnosis, and treatment in a 53-year-old male smoker who presents with arm pain and dusky cool fingers. A Buerger diagnosis requires exclusion of autoimmune, diabetic, and embolic causes. The only recognized treatment for this disease is smoking cessation.

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Section: Discussionmentioning

confidence: 99%

Thromboangiitis obliterans (Buerger disease)

Seebald

Gritters

2015

Radiology Case Reports

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“…Its nature is similar to ischemic atherosclerosis diseases of the limbs, but its pathogenesis and pathological behavior are different from those of other ischemic arterial diseases. There is lack of effective quantitative indicators for the treatment and diagnosis of TO (Chai et al, 2013;Pavlic et al, 2013;Yang et al, 2013;Fazeli et al, 2014;Ozbek et al, 2014;Ramin et al, 2014). HIF-1α is the most important regulatory factor in hypoxic ischemia diseases (Tong et al, 2012), and it has wide potential in TO diagnosis, treatment, evaluation of operation effectiveness, and relapse monitoring.…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans

He¹,

Qu²,

Wang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the expression and effects of hypoxiainducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min after injection in both groups, and physiological changes were observed at different times (gross observation and hematoxylin and eosin staining). The animals were killed at various times following the operation and serum and muscle tissues were sampled. For the sham group: the endometrium was relatively intact; medial membrane and epineurium lesions were absent; and blood vessels and surrounding tissues had no inflammatory cell infiltration. For the model group: all subgroups displayed inflammation; large numbers of inflammatory cells were gathered; muscle tissue lost its normal texture and structure; and the internal elastic membrane was integrated. Compared with the preoperative status, HIF-1α expression increased significantly in all subgroups (P < 0.05); there was no change in the sham group. HIF-1α expression in each subgroup was different (F = 14.267, P < 0.05). Femoral artery injection of lauric acid can be used as T. He et al. 6716©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6715-6722 (2015) a rat TO model owing to its simple application and success rate. HIF-1α expression increased in the early stage of TO and gradually decreased with the extension of ischemia time; it may play a leading role in TO development and can be used for diagnosis and cure evaluation.

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“…Az atherosclerosis patogeneziséhez hasonlóan Buerger-kórban is felmerült a krónikus gyulladásos folyamatok jelentősége. Érdekesség, hogy periodontalis fertőzéseknek is jelentőséget tulajdonítanak [13].…”

Section: Megbeszélésunclassified

Thromboangitis obliterans agyi manifesztációja

Aszalos¹,

Dongó

Farkas

et al. 2016

Orvosi Hetilap

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A thromboangitis obliterans (Buerger-kór) nem atherosclerosisos, a kis-és közepes méretű artériák és vénák szegmentális gyulladásával és thromboticus elzáródásával járó perifériás érbetegség. Etiológiája a mai napig ismeretlen, szoros összefüggést mutat a dohányzással. A tünetek 45 éves kor előtt kezdődnek, jellegzetes a hullámzó kórlefolyás. A végtagok acralis részein akut és krónikus ischaemiás vagy infektív tünetek alakulnak ki. A Buerger-kór diagnózisa elsősorban a klinikai képen és az angiográfiás vizsgálaton alapul, de alapvetően fontos autoimmun betegség, thrombophilia, diabetes mellitus és proximalis emboliaforrás kizárása is. A betegség leggyakrabban a végtagok ereit érinti, ritkán azonban érintettek lehetnek az agyi, a coronaria-és a zsigeri artériák is. A szerzők 49 éves, korábban már Buerger-kór miatt kezelt férfi kórtörténetéről számolnak be, akinél akut ischaemiás stroke-ot diagnosztizáltak. Kép-alkotó vizsgálatokkal akut és krónikus ischaemiás laesiókat, valamint a tünetképző oldalon az arteria cerebri media nem atheroscleroticus arteriopathiáját igazolták. A részletes kivizsgálás során más etiológiát nem találtak. Orv. Hetil., 2016, 157(30), 1207-1211. Kulcsszavak: thromboangitis obliterans, dohányzás, ischaemiás stroke Cerebral manifestations of thromboangiitis obliterans Case reportThromboangiits obliterans (Buerger's disease) is a non-atherosclerotic, segmental inflammatory and obliterative disease affecting small and medium sized arteries and veins. The etiology is still unknown, but it is in close relationship with tobacco use. Symptoms begin under the age of 45 years and the undulating course is typical. Patients usually present with acute and chronic ischemic or infectious acral lesions. Diagnosis is usually based on clinical and angiographic criteria and it is important to exclude autoimmune disease, thrombophilia, diabetes, and proximal embolic sources. Even though Buerger's disease most commonly involves the arteries of the extremities, the pathologic findings sometimes affect the cerebral, coronary and internal thoracic, renal and mesenteric arteries as well. The authors present the history of a patient with known Buerger's disease and acute ischemic stroke. Brain imaging detected acute and chronic ischemic lesions caused by middle cerebral non-atherosclerotic arteriopathy on the symptomatic side. Other etiology was excluded by detailed investigations.

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Periodontitis and Buerger's Disease: Recent Advances

Cited by 14 publications

References 26 publications

Thromboangiitis obliterans (Buerger disease)

Thromboangiitis obliterans (Buerger disease)

Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans

Thromboangitis obliterans agyi manifesztációja

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