Periodontal tissue activation by vibration: Intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats

Nishimura, Makoto; Chiba, Momoko; Ohashi, Toshiro; Sato, Masaaki; Shimizu, Yoshiyuki; Igarashi, Kaoru; Mitani, Hideo

doi:10.1016/j.ajodo.2006.01.046

Cited by 222 publications

(178 citation statements)

References 38 publications

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“…[24][25][26] In animal models, vibrational force has been shown to promote bony remodelling at sutures 27,28 and speed up orthodontic tooth movement. 29,30 Based on these data, several devices have been developed that are now commercially available and designed to deliver vibrational force directly to the dentition. One of these, AcceleDent® is a hands-free removable portable appliance consisting of an activator unit and mouthpiece, which provides a vibrational frequency of 30 Hz and force of 0.2 N. The patient bites gently onto a vibrating thermoplastic wafer, which is in contact with the occlusal surface of both the maxillary and mandibular dentitions.…”

Section: Introduction Backgroundmentioning

confidence: 99%

Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: A multicenter randomized clinical trial

DiBiase

Woodhouse

Papageorgiou

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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INTRODUCTION A multicenter parallel 3-arm randomized clinical trial was carried out in 1 university and 2 district hospitals in the United Kingdom to investigate the effect of supplemental vibrational force on orthodontically induced inflammatory root resorption (OIIRR) during the alignment phase of fixed appliance therapy. METHODS Eighty-one subjects less than 20 years old with mandibular incisor irregularity undergoing extraction-based fixed-appliance treatment were randomly allocated to supplementary (20 minutes a day) use of an intraoral vibrational device (AcceleDent; OrthoAccel Technologies, Houston, Tex) (n = 29), an identical nonfunctional (sham) device (n = 25), or fixed appliances only (n = 27). OIIRR was measured blindly from long-cone periapical radiographs of the maxillary right central incisor taken at the start of treatment and the end of alignment when a 0.019 × 0.025-in stainless steel archwire was placed (mean follow-up, 201.6 days; 95% confidence interval [CI], 188.6-214.6 days). Data were analyzed blindly on a per-protocol basis because losses to follow-up were minimal, with descriptive statistics, 1-way analysis of variance, and univariable and multivariable regression modeling. RESULTS Nine patients were excluded from the analysis; they were evenly distributed across the groups. Mean overall OIIRR measured among the 72 patients was 1.08 mm (95% CI, 0.89-1.27 mm). Multivariable regression indicated no significant difference in OIIRR for the AcceleDent (difference, 0.22 mm; 95% CI, -0.14-0.72; P = 0.184) and AcceleDent sham groups (difference, 0.29 mm; 95% CI, -0.15-0.99; P = 0.147) compared with the fixed-appliance-only group, after accounting for patient sex, age, malocclusion, extraction pattern, alignment time, maximum pain experienced, history of dentoalveolar trauma, and initial root length of the maxillary right central incisor. No other side-effects were recorded apart from pain and OIIRR. CONCLUSIONS The use of supplemental vibrational force during the alignment phase of fixed appliance orthodontic treatment does not affect OIIRR associated with the maxillary central incisor. REGISTRATION ClinicalTrials.gov (NCT02314975). PROTOCOL The protocol was not published before trial commencement. FUNDING Functional and sham AcceleDent units were donated by the manufacturer; there was no contribution to the conduct or the writing of this study.

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Section: Introduction Backgroundmentioning

confidence: 99%

Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: A multicenter randomized clinical trial

DiBiase

Woodhouse

Papageorgiou

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Local LMHF vibrational stimulation can also impart beneficial effects on bone. It is reported that orthodontic tooth movement is accelerated by local resonant vibration (Nishimura et al 2008). However, the optimal parameters necessary to maximize the beneficial effects of vibration on bone, such as acceleration and frequency, remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Vibrational stimulation induces osteoblast differentiation and the upregulation of osteogenic gene expression in vitro

2016

Self Cite

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Vibrational stimulation is an accepted non-invasive method used to improve bone remodeling. However, the underlying mechanisms of this phenomenon remain unclear. In this study, we developed a new vibration-loading system to apply vibrational stimulation to cells based on a previously reported in vivo study. We hypothesized that osteoblasts respond to vibrational strain by expressing osteogenic marker genes, such as alkaline-phosphatase (ALP), Runx2, and Osterix. To test our hypothesis, we developed a vibration-loading system to apply a precise vibrational force to an osteoblast culture on a silicone membrane. The system regulated frequency and acceleration of the vibration, and strain on the silicone membrane culture surface was measured using the strain gauge method. After vibrational stimulation, cellular gene expression was analyzed using real-time polymerase chain reaction. We obtained clear strain signals from the culture surface at vibrational ranges of 1.0-10 m/s 2 acceleration and frequencies of 30, 60, and 90 Hz, respectively. The strain increased in a linear fashion, depending on the acceleration magnitude. Vibrational stimulation also significantly upregulated expression of the osteogenic marker genes Runx2, Osterix, type I collagen, and ALP. In conclusion, we developed a new vibrationloading system that can precisely regulate frequency and acceleration, and we established the presence of dynamic cellular strain on a culture surface. Our findings suggest that vibrational stimulation may directly induce osteoblast differentiation.

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“…To date, several novel modalities have been reported to accelerate orthodontic tooth movement, including low-level laser therapy, 8,9 pulsed electromagnetic fields, 10 electrical currents, 11 corticotomy, 12,13 distraction osteogenesis, [14][15][16] and mechanical vibration. 17 However, pertinent results are inconclusive, and some are unreliable, which may bias clinicians' understandings and mislead clinical practice. Thus, a critical systematic review would be quite beneficial for clinicians.…”

Section: Introductionmentioning

confidence: 99%

Interventions for accelerating orthodontic tooth movement

Long

Pyakurel

Wang

et al. 2012

The Angle Orthodontist

178

136

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Objective: To evaluate the effectiveness of interventions on accelerating orthodontic tooth movement. Materials and Methods: We searched the databases of PubMed, Embase, Science Citation Index, CENTRAL, and SIGLE from January 1990 to August 2011 for randomized or quasirandomized controlled trials that assessed the effectiveness of interventions on accelerating orthodontic tooth movement. The processes of study search, selection, and quality assessment were conducted independently in duplicate by two review authors. Original outcome data, if possible, underwent statistical pooling by using Review Manager 5. Results: Through a predefined search strategy, we finally included nine eligible studies. Among them, five interventions were studied (ie, low-level laser therapy, corticotomy, electrical current, pulsed electromagnetic fields, and dentoalveolar or periodontal distraction). Six outcomes were evaluated in these studies (ie, accumulative moved distance or movement rate, time required to move tooth to its destination, anchorage loss, periodontal health, pulp vitality, and root resorption). Conclusion: Among the five interventions, corticotomy is effective and safe to accelerate orthodontic tooth movement, low-level laser therapy was unable to accelerate orthodontic tooth movement, current evidence does not reveal whether electrical current and pulsed electromagnetic fields are effective in accelerating orthodontic tooth movement, and dentoalveolar or periodontal distraction is promising in accelerating orthodontic tooth movement but lacks convincing evidence. (Angle Orthod. 2013;83:164-171.)

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Periodontal tissue activation by vibration: Intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats

Cited by 222 publications

References 38 publications

Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: A multicenter randomized clinical trial

Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: A multicenter randomized clinical trial

Vibrational stimulation induces osteoblast differentiation and the upregulation of osteogenic gene expression in vitro

Interventions for accelerating orthodontic tooth movement

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