2015
DOI: 10.1007/s40496-015-0060-0
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Abstract: Periodontal tissue is susceptible to chronic periodontal disease, which results in irreversible tissue destruction. Adult stem cells can be obtained from the periodontal ligament of the periodontium. Stem cells from the periodontal ligament (PDLSCs) are promising for periodontal regeneration because they can undergo guided differentiation under specialized conditions. Currently, growth factors and scaffolds are used for differentiation and clinical application of PDLSCs. In this review, characteristics of PDLS… Show more

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Cited by 13 publications
(13 citation statements)
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“…Studies similar to ours are uncommon and seldom focused on the osteoblast differentiation of PDLSCs by AGEs. As an autologous source of adult stem cells, PDLSCs have potential therapeutic application value to patients with diabetes mellitus 2, 3, 4, 5, 6. Studies similar to ours are uncommon and relate to other factors.…”
Section: Discussionmentioning
confidence: 59%
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“…Studies similar to ours are uncommon and seldom focused on the osteoblast differentiation of PDLSCs by AGEs. As an autologous source of adult stem cells, PDLSCs have potential therapeutic application value to patients with diabetes mellitus 2, 3, 4, 5, 6. Studies similar to ours are uncommon and relate to other factors.…”
Section: Discussionmentioning
confidence: 59%
“…They also affect typical periodontal ligament-like tissues to regenerate tissues damaged by periodontitis. Its regeneration potential contributes to its self-renewal and multi-differentiation ability, especially osteogenesis differentiation 4 , 5 . It is suggested that PDLSCs can provide an important cell source for the treatment of periodontal disease mediated by stem cells 6 …”
Section: Introductionmentioning
confidence: 99%
“…Periodontal ligament stem cells (PDLCs), adult stem cells have potential to utilize in regenerative medicine applications, owing to their distinctive localization and differentiation properties into fibrogenic and osteogenic (10,11). PDLCs have the capacity to differentiate into keratocytes, cementoblasts, and osteoblasts cells in the presence of cell inducing factors and scaffolds.…”
Section: Introductionmentioning
confidence: 99%
“…For example, PDLCs shared many osteoblast-like properties, including expression of the alkaline phosphatase as aboneassociated marker, response to bone-inductive factors, and the capacity to form mineralized nodules in in vitro. PDLCs behavior in alginate microparticle was provided as a reliable approach for bone tissue engineering and regenerative medicine (8,10,11). PDLCs in Chitosannanohydroxyapatite scaffold could induce osteogenic and adipogenic differentiation in vitro and in vivo (9).…”
Section: Introductionmentioning
confidence: 99%
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