2015
DOI: 10.1159/000351894
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Abstract: The periodontal ligament (PDL) and alveolar bone are two critical tissues for understanding orthodontic tooth movement. The current literature is replete with descriptive studies of multiple cell types and their matrices in the PDL and alveolar bone, but is deficient with how stem/progenitor cells differentiate into PDL and alveolar bone cells. Can one type of orthodontic force with a specific magnitude and frequency preferably activate osteoblasts, whereas another force type activates osteoclasts? This chapte… Show more

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Cited by 115 publications
(91 citation statements)
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“…The human periodontal ligament (hPDL) is a richly vascular and cellular connective tissue that surrounds the roots of teeth and joins the root cementum to the socket wall of the dental alveolus 1 . hPDL plays a vital role in sustaining teeth, maintenance of periodontal homeostasis, and damage repair in response to mechanical trauma or periodontal inflammation 2,3 .…”
mentioning
confidence: 99%
“…The human periodontal ligament (hPDL) is a richly vascular and cellular connective tissue that surrounds the roots of teeth and joins the root cementum to the socket wall of the dental alveolus 1 . hPDL plays a vital role in sustaining teeth, maintenance of periodontal homeostasis, and damage repair in response to mechanical trauma or periodontal inflammation 2,3 .…”
mentioning
confidence: 99%
“…We further checked the expression of those genes in the periapical tissues of children who had experienced both delayed permanent tooth eruption, as well as having presented the primary teeth for an extended time as “persistent primary teeth.” It is important to emphasize that in the present study, the periodontal ligament was chosen for the genes expression analysis due to its importance in the process of root resorption. The periodontal ligament presents osteoclasts in its constitution . Also, it has been demonstrated that the cells in the periodontal ligament express RANKL and decreased expression of OPG during root resorption …”
Section: Discussionmentioning
confidence: 99%
“…The periodontal ligament presents osteoclasts in its constitution. 21 Also, it has been demonstrated that the cells in the periodontal ligament express RANKL and decreased expression of OPG during root resorption. 22 Eruption is the developmental process, in which a tooth moves from its crypt position through the alveolar process into the oral cavity to its final position of occlusion with its antagonist.…”
Section: Discussionmentioning
confidence: 99%
“…Although only a small proportion consider this painful feeling to be significant and a minority will interrupt orthodontic treatment because of it, using analgesics for a few days to relieve this pain is common . Since any medication taken may impact the biochemical processes leading to orthodontic tooth movement, a thorough understanding of their effects is necessary . Current information originating from human trials regarding the effect of analgesics is limited to two studies, investigating the non‐steroidal anti‐inflammatory drugs nabumetone and tenoxicam …”
Section: Introductionmentioning
confidence: 99%