Periodontal infection and subclinical atherosclerosis: the role of high‐density lipoprotein as a modifying factor

Ylöstalo, Pekka; Anttila, Sirpa; Rajala, Ulla; Pãivänsalo, M.; Keinänen‐Kiukaanniemi, Sirkka; Sakki, Tero K.; Knuuttila, Matti

doi:10.1111/j.1600-051x.2010.01572.x

Cited by 13 publications

(9 citation statements)

References 19 publications

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“…To date, using these data, we have not studied whether subjects with simultaneous severe periodontal infection and unfavourable lipid composition are truly at higher risk of cardiovascular disease compared with subjects with the single risk of periodontal infection or unfavourable lipid composition. At present, there is little to support such an interpretation, but the results of this study, which would seem to be a fairly new finding, are in agreement with the finding of our earlier study in which we reported that periodontal infection was associated with atheroma formation among subjects with low HDL (Ylo¨stalo et al 2010). Whether it is the case of a true interaction remains to be confirmed in future studies.…”

Section: Implications Of the Studysupporting

confidence: 89%

Serum lipids modify periodontal infection ‐ C‐reactive protein association

Haro

Saxlin

Suominen³

et al. 2012

J Clinic Periodontology

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Section: Implications Of the Studysupporting

confidence: 89%

Serum lipids modify periodontal infection ‐ C‐reactive protein association

Haro

Saxlin

Suominen³

et al. 2012

J Clinic Periodontology

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“…Considerations should also be given when the positive correlations between OB, BMI and HDL in the CP group take into account. As known, hs-CRP and blood lipid levels were suggested to be important markers to have a role in the relationship between periodontal disease and the systemic diseases [50][51][52]. Accordingly, this result, when related to the systemic effect of the chronic local inflammation, may explain the relationship (directional or bi-directional) between the periodontal and systemic diseases when the systemic effects of adipokines (cardiovascular, obesity and diabetes mellitus [53]) are considered.…”

Section: Discussionmentioning

confidence: 88%

The gingiva contains leptin and leptin receptor in health and disease

Kırzıoğlu

Tonguç

et al. 2011

Odontology

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The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P > 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P < 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P < 0.05), with hs-CRP in G (P < 0.05) and AP groups (P < 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P < 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.

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“…Recent studies indicated that periodontitis may be a risk factor for worsening glycemic control, impairing endothelial function among patients with diabetes, and also may increase the risk of cardiovascular events, such as myocardial infarction and stroke. hsCRP and HDL are two risk markers for cardiovascular disease (28,29). And an epidemiological extrapolation from the UK Prospective Diabetes Study (UKPDS) predicts that for every 1% reduction in HbA1c there would be an associated 21% reduction in risk for any diabetes-related endpoints, including both microvascular (37% reduced risk of microvascular complications) and macrovascular (14% reduced risk of myocardial infarction) complications (30).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

et al. 2011

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Objective To evaluate the effects of periodontal intervention on inflammatory cytokines, adiponectin, insulin resistance (IR), and metabolic control and to investigate the relationship between type 2 diabetes mellitus (T2DM) and moderately poor glycemic control and chronic periodontitis. Methods and Patients A total of 190 moderately poorly controlled (HbA1c between 7.5% and 9.5%) T2DM patients with periodontitis were randomly divided into two groups according to whether they underwent periodontal intervention: T2DM-NT and T2DM-T group. The levels of serum adiponectin, C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), lipid profile, glucose, insulin, homeostasis model of assessment -insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were measured at baseline and after 3 months. Results The levels of clinical periodontal variables, the probing depth, attachment loss, bleeding index, and plaque index were improved significantly in T2DM-T group after 3 months compared to T2DM-NT group (all p<0.01). After 3 months, the serum levels of hsCRP, TNF-α, IL-6, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and HOMA-IR index decreased, and adiponectin was significantly increased in T2DM-T group compared to those in the T2DM-NT group (p<0.05 or p<0.01). Conclusion Periodontal intervention can improve glycemic control, lipid profile and IR, reduce serum inflammatory cytokine levels and increase serum adiponectin levels in moderately poorly controlled T2DM patients.

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Periodontal infection and subclinical atherosclerosis: the role of high‐density lipoprotein as a modifying factor

Abstract: HDL levels or factors closely associated with HDL levels appear to modify the association between periodontal infection and certain parameters of subclinical atherosclerosis.

Cited by 13 publications

References 19 publications

Serum lipids modify periodontal infection ‐ C‐reactive protein association

Serum lipids modify periodontal infection ‐ C‐reactive protein association

The gingiva contains leptin and leptin receptor in health and disease

Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

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