Periodontal Diseases: A Covert Focus of Inflammation in Pulmonary Diseases

Gupta, Abhaya; Verma, Umesh Pratap; Verma, Ajay Kumar; Choudhary, Shyam Chand; Sharma, Sakshi; Singh, Neetu; Sharma, Disha

doi:10.4103/ijrc.ijrc_15_18

Cited by 2 publications

(1 citation statement)

References 69 publications

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“…Interestingly, there exists evidence to suggest that treating periodontitis may improve lung function in people with COPD. Through reviewing the published literature of the last four decades, Gupta et al 20 concluded that periodontal attachment loss had an impact on the risk of COPD occurrence and that periodontal treatment could reduce COPD exacerbations. Kucukcoskun et al 21 equally divided 40 COPD patients with periodontitis into two groups, a control group without intervention and a treatment group with periodontal treatment.…”

Section: Association Between Periodontitis and Copdmentioning

confidence: 99%

Research on the Association Between Periodontitis and COPD

Xiong,

Yang,

Cui

et al. 2023

COPD

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Periodontitis is a common chronic bacteria-initiated inflammatory disease that is closely associated with various systemic diseases, including chronic obstructive pulmonary disease (COPD). Periodontitis and COPD share similar risk factors, pathology and microorganisms. Epidemiological and clinical research have shown positive correlation between the two diseases. Individuals with severe periodontitis had a higher risk of developing COPD. Moreover, the relative risk of COPD in severe periodontitis was much higher compared to people without periodontal disease and patients with mild to moderate periodontitis. COPD patients with periodontitis had a higher frequency of COPD exacerbation and periodontal treatment demonstrated some control of COPD. However, the nature of periodontitis affecting COPD still needs further exploration. Periodontitis caused microbial and immune imbalances of the lung through several aspects: (I) under periodontitis status, periodontal pathogens directly caused the lung inflammatory reaction after inhalation and colonization on the lung, (II) periodontitis status promoted the oral colonization of pneumonia-associated pathogens, (III) periodontitis status affected the respiratory epithelium structure and (IV) periodontitis status caused imbalances in neutrophils, macrophages and inflammatory cytokines. In this review, we conclude the association between periodontitis and COPD through several aspects and further discuss the potential mechanism by which periodontitis affects COPD.

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Section: Association Between Periodontitis and Copdmentioning

confidence: 99%

Research on the Association Between Periodontitis and COPD

Xiong,

Yang,

Cui

et al. 2023

COPD

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Factors affecting readmitted patients with acute exacerbation of bronchiectasis

Alduihi

Khoury

2019

Egypt J Intern Med

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Background Bronchiectasis is an important cause of morbidity and mortality all over the world. Determining the frequency of actual occurrence is particularly misleading and difficult to determine, especially in patients with multiple respiratory disorders, because it can be a result of any primary pulmonary disease. The objective of this study was to evaluate the effect of readmission with acute exacerbation of bronchiectasis (AEB) on the admissions later on, need of long-term O2 and mechanical ventilation, and mortality. Patients and methods This is an observational cohort and prospective study. It was conducted on patients admitted with AEB who achieved modified O’Donnell criteria, and their high-resolution computed tomography showed bronchiectasis on admission at Aleppo University Hospital between September 2017 and January 2019. They were divided into three groups by age. Patients with bronchial asthma, chronic obstructive pulmonary disease, and cystic fibrosis were excluded. Results The study included 90 patients (57 males and 33 females) with a mean age of 52.93 ±20.437 years. AEB showed a peak of incidence in the age group 41–65 years. Dyspnea is the most common symptom in exacerbations (88.23%) followed by hemoptysis (80.88%). Wheezing had the least frequency on admission (60.29%). Median survival age was 14±0.214 months. We collected information on 136 exacerbations in 90 patients. A total of 31 (34.44%) patients had at least one readmission and 19 (21%) patients died within 12 months of admission to the hospital. Age, smoking, and need of long-term O2 were statistically significant between the two groups of study (P=0.013, <0.0001, and 0.04, respectively). Sex, radiological changes, mortality, and mechanical ventilation have no significance. Conclusion AEB is a common reason for hospitalization, and it correlates with age, smoking, readmission, and need of long-term O2 treatment.

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Periodontal Diseases: A Covert Focus of Inflammation in Pulmonary Diseases

Cited by 2 publications

References 69 publications

Research on the Association Between Periodontitis and COPD

Research on the Association Between Periodontitis and COPD

Factors affecting readmitted patients with acute exacerbation of bronchiectasis

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