Perineural invasion in skin cancer of the head and neck

What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion?

“…All 3 of the patients in that study who received adjuvant XRT had 100% local control with no evidence of disease at follow-up between 18 months and 201 months. 26 All 6 patients who did not receive adjuvant XRT in that study also had 100% local control, suggesting that aggressive surgical treatment of advanced SCC patients, with or without adjuvant XRT, may achieve long-term disease control as long as the tumor is recognized and treated adequately prior to its entry into the cranial cavity.…”

What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion?

“…All 3 of the patients in that study who received adjuvant XRT had 100% local control with no evidence of disease at follow-up between 18 months and 201 months. 26 All 6 patients who did not receive adjuvant XRT in that study also had 100% local control, suggesting that aggressive surgical treatment of advanced SCC patients, with or without adjuvant XRT, may achieve long-term disease control as long as the tumor is recognized and treated adequately prior to its entry into the cranial cavity.…”

Adjunctive radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion

“…No patients died of recurrent skin cancer, and those that died due to other causes had no residual skin cancer. The disease free survival rate was 100% 8.…”

Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma

“…10,21,24,27,28,30,31 The risk of local recurrence ranged from 13% to 23%, while the risk of nodal metastasis ranged from 9% to 17%. One study had no occurrences of local recurrence or nodal metastasis.…”

“…The remaining 42 articles were reviewed in detail for eligibility. After exclusion criteria were applied, 30 articles were excluded, leaving 12 studies included in the systematic review …”

“…Most of the studies (8 [67%]) were retrospective, and the remainder were case series or case reports (4 [33%]) (Table 1). The median follow-up time ranged from 19 to 89 months. The studies included a total of 640 tumors with CPNI or IPNI in 622 patients.…”

What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion?

“…All 3 of the patients in that study who received adjuvant XRT had 100% local control with no evidence of disease at follow-up between 18 months and 201 months. 26 All 6 patients who did not receive adjuvant XRT in that study also had 100% local control, suggesting that aggressive surgical treatment of advanced SCC patients, with or without adjuvant XRT, may achieve long-term disease control as long as the tumor is recognized and treated adequately prior to its entry into the cranial cavity.…”

Adjunctive radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion

“…No patients died of recurrent skin cancer, and those that died due to other causes had no residual skin cancer. The disease free survival rate was 100% 8.…”

Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma

“…10,21,24,27,28,30,31 The risk of local recurrence ranged from 13% to 23%, while the risk of nodal metastasis ranged from 9% to 17%. One study had no occurrences of local recurrence or nodal metastasis.…”

“…The remaining 42 articles were reviewed in detail for eligibility. After exclusion criteria were applied, 30 articles were excluded, leaving 12 studies included in the systematic review …”

“…Most of the studies (8 [67%]) were retrospective, and the remainder were case series or case reports (4 [33%]) (Table 1). The median follow-up time ranged from 19 to 89 months. The studies included a total of 640 tumors with CPNI or IPNI in 622 patients.…”

What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion?

“…All 3 of the patients in that study who received adjuvant XRT had 100% local control with no evidence of disease at follow-up between 18 months and 201 months. 26 All 6 patients who did not receive adjuvant XRT in that study also had 100% local control, suggesting that aggressive surgical treatment of advanced SCC patients, with or without adjuvant XRT, may achieve long-term disease control as long as the tumor is recognized and treated adequately prior to its entry into the cranial cavity.…”

Adjunctive radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion

“…No patients died of recurrent skin cancer, and those that died due to other causes had no residual skin cancer. The disease free survival rate was 100% 8.…”

Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma

“…10,21,24,27,28,30,31 The risk of local recurrence ranged from 13% to 23%, while the risk of nodal metastasis ranged from 9% to 17%. One study had no occurrences of local recurrence or nodal metastasis.…”

“…The remaining 42 articles were reviewed in detail for eligibility. After exclusion criteria were applied, 30 articles were excluded, leaving 12 studies included in the systematic review …”

“…Most of the studies (8 [67%]) were retrospective, and the remainder were case series or case reports (4 [33%]) (Table 1). The median follow-up time ranged from 19 to 89 months. The studies included a total of 640 tumors with CPNI or IPNI in 622 patients.…”