Perinatal toxicity of endrin in rodents. I. Fetotoxic effects of prenatal exposure in hamsters

Abstract

The potential of the insecticide endrin to induce fetal toxicity was determined in hamsters exposed to the compound on either day 8 or days 5--14 of gestation. Endrin was administered by oral gavage as a solution in corn oil. Doses used included 0.5--10.0 mg/kg on day 8 and 0.75 to 3.5 mg/kg/day on days 5--14. Exposure to a single dose of endrin resulted in significant incidences of fused ribs and meningoencephaloceles at levels of 5 mg/kg or greater. No significant effects were noted in either maternal mortality and weight gain or in fetal mortality or weight gain. The administration of multiple doses of endrin resulted in few fetal defects, although a significant dose-related increase in fetal mortality and decrease in fetal weight was seen. Significant maternal lethality and weight reductions were noted at doses of 1.5 mg/kg/day or greater. At sacrifice, maternal liver and fetal tissues were collected and subsequently analyzed for endrin and a major metabolite, 12-ketoendrin. Endrin was found to cross the placenta and 20 ppb were found in fetuses from litters exposed to 2.5 mg/kg/day. Maternal livers from this dose group contained an average of 2500 pbb of endrin.

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

“…Hepatic effects of endrin exposure have included necrosis, fatty infiltration, and inflammation (Smith, 1991). Skeletal abnormalities and cleft palate in the offspring were associated with endrin when it was fed to pregnant laboratory rodents (Chernoff et al, 1979;Kavlock et al, 1981).…”

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

“…Hepatic effects of endrin exposure have included necrosis, fatty infiltration, and inflammation (Smith, 1991). Skeletal abnormalities and cleft palate in the offspring were associated with endrin when it was fed to pregnant laboratory rodents (Chernoff et al, 1979;Kavlock et al, 1981).…”

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

“…Hepatic effects of endrin exposure have included necrosis, fatty infiltration, and inflammation (Smith, 1991). Skeletal abnormalities and cleft palate in the offspring were associated with endrin when it was fed to pregnant laboratory rodents (Chernoff et al, 1979;Kavlock et al, 1981).…”

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

“…Hepatic effects of endrin exposure have included necrosis, fatty infiltration, and inflammation (Smith, 1991). Skeletal abnormalities and cleft palate in the offspring were associated with endrin when it was fed to pregnant laboratory rodents (Chernoff et al, 1979;Kavlock et al, 1981).…”