Perinatal lipocalin-2 profile at the extremes of fetal growth

Papathanasiou, Aimilia Eirini; Malamitsi‐Puchner, Ariadne; Gavrili, Stavroula; Zachaki, Sophia; Georgantzi, Sophia; Marmarinos, Antonios; Christou, Christos; Voulgaris, Konstantinos; Gourgiotis, Dimitrios; Briana, Despina D.

doi:10.1080/14767058.2019.1659774

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…In the previously mentioned cross-sectional study, lipocalin-2 in cord blood at birth was also analyzed [114]. Lipocalin-2 levels in cord blood were significantly increased when compared to levels found in maternal serum, and they were also significantly elevated in the IUGR group when compared to the LGA group [114].…”

Section: Cord Blood Lipocalin-2mentioning

confidence: 99%

“…To examine the relationship between maternal circulating lipocalin-2 and parameters of intrauterine growth, Papasthanasiou et al, performed a cross-sectional study on a population including 80 mothers and their offspring, who were divided into AGA, LGA and IUGR groups [114]. They found a significant increase in maternal lipocalin-2 levels in mothers who later delivered AGA infants when compared to mothers who later delivered LGA neonates or neonates with IUGR [114].…”

Section: Lipocalin-2 and Parameters Of Intrauterine Growthmentioning

confidence: 99%

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Adipokines in Pregnancy: A Systematic Review of Clinical Data

et al. 2023

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Adipokines are signaling proteins involved in metabolic, endocrinological, vascular and immunogenic processes. Associations of various adipokines with not only insulin resistance but also with increased insulin sensitivity, increased systolic blood pressure, and atherosclerosis highlight the significance of adipokines in several components of metabolic syndrome and metabolic diseases in general. As pregnancy presents a unique metabolic state, the role of adipokines in pregnancy, and even in various pregnancy complications, appears to be key to elucidating these metabolic processes. Many studies in recent years have attempted to clarify the role of adipokines in pregnancy and gestational pathologies. In this review, we aim to investigate the changes in maternal adipokine levels in physiological gestation, as well as the association of adipokines with pregnancy pathologies, such as gestational diabetes mellitus (GDM) and preeclampsia (PE). Furthermore, we will analyze the association of adipokines in both maternal serum and cord blood with parameters of intrauterine growth and various pregnancy outcomes.

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Section: Cord Blood Lipocalin-2mentioning

confidence: 99%

Section: Lipocalin-2 and Parameters Of Intrauterine Growthmentioning

confidence: 99%

Adipokines in Pregnancy: A Systematic Review of Clinical Data

et al. 2023

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“…For example, Briana et al reported higher levels of umbilical cord preadipocyte factor-1 (pref-1) at partum in comparison to levels found in maternal serum antepartum, indicating the fetal origin of cord pref-1 [ 25 ]. Likewise, lipocalin-2 was also found to be increased in cord serum and is therefore most likely of fetal origin [ 26 ]. As our cohort included exclusively healthy, term babies born at an appropriate weight (2500–4500 g) for gestational age (AGA), we speculate that fetal secretion of TGFβ1 is a physiological process and is associated with normal fetal and child development.…”

Section: Discussionmentioning

confidence: 99%

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

et al. 2023

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Transforming growth factor beta-1 (TGFβ1) is an adipokine secreted from adipose tissue, placental tissue and immune cells with a role in cell proliferation, cell apoptosis and angiogenic proliferation. The role of TGFβ1 in pregnancy and child growth and the source of cord TGFβ1 are yet unknown. In this study, we sought to clarify the correlation of TGFβ1 levels with parameters of intrauterine growth and child growth during the first year of life, and to determine whether their source is primarily of fetal or maternal origin. Serum samples and anthropometric measurements were obtained from the LIFE Child cohort of 79 healthy mother–child pairs. Measurements were conducted using enzyme-linked immunosorbent assays. Statistical analyses including Mann–Whitney U-test, correlation analyses and linear regression analyses were performed using GraphPad Prism and R. TGFβ1 levels were significantly higher in cord than in maternal serum, suggesting a fetal origin. Multivariate regression analyses revealed strong positive associations between cord TGFβ1 levels at birth and child weight at U6. Furthermore, cord TGFβ1 was significantly correlated with child weight at approximately one year of age. An increase of 10,000 pg/mL in cord TGFβ1 concentrations at birth was associated with a higher body weight of 201 g at roughly one year of age when adjusted for sex.

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“…The latest studies indicated NGAL use as a diagnostic and prognostic biomarker for acute kidney injury in the adult and pediatric population [7][8][9]. Authors suggested that NGAL increase may be characteristic for mothers with preeclampsia and their SGA infants alike [7,8,10,11].…”

Section: Introductionmentioning

confidence: 99%

Malondialdehyde and Neutrophil Gelatinase-Associated Lipocalin as Markers of Oxidative Stress in Small for Gestational Age Newborns from Hypertensive and Preeclamptic Pregnancies

Surmiak

Wojnarowicz

Szymkowiak

2022

BioMed Research International

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Introduction. It is speculated that preeclampsia and hypertension during pregnancy are associated with an imbalance of the placental antioxidant defence, which results in the overproduction of reactive oxygen species and fetal growth restriction. Many research implied that oxidant stress in utero may be an important determinant of mortality and morbidity in neonates. Moreover, the authors demonstrated the reduced number of nephrons and a higher prevalence of renal injury in neonates with growth restriction, including small for gestational age (SGA) neonates. Alas, it remains unclear whether basal antioxidant status is altered in the kidneys of SGA newborns. Materials and Methods. In this study, we assessed neutrophil gelatinase-associated lipocalin (NGAL) and malondialdehyde (MDA) levels in samples collected from umbilical blood and 12 hours after delivery in neonates born by mothers suffering from preeclampsia or hypertension during pregnancy and those from physiological pregnancies. Additionally, the authors evaluated levels of the aforementioned biomarkers regarding the occurrence of growth restriction in newborns. For this study, we enrolled 27 newborns, which fulfilled inclusion criteria for SGA diagnosis (SGA group), while 21 were appropriate for gestational age neonates, as the AGA group. Results. In the presented study, we have found significant differences in umbilical cord MDA and NGAL concentration between the SGA and AGA groups. Such dependencies were not found in blood samples from neonates collected in the first 12 hours of life for MDA and NGAL concentrations. Additionally, we have observed differences in umbilical MDA and NGAL levels between newborns of preeclamptic or hypertensive mothers compared to healthy ones. A significant correlation between the occurrence of hypertension during pregnancy and umbilical MDA and NGAL concentrations was also found. Conclusions. Small for gestational age newborns or those born by preeclamptic and hypertensive mothers had significantly higher MDA and NGAL levels as compared to healthy ones. Further investigation is needed to understand the pathophysiologic influence of hypertension in pregnancy and oxidative stress injury in newborns with growth restriction.

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Perinatal lipocalin-2 profile at the extremes of fetal growth

Cited by 6 publications

References 32 publications

Adipokines in Pregnancy: A Systematic Review of Clinical Data

Adipokines in Pregnancy: A Systematic Review of Clinical Data

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

Malondialdehyde and Neutrophil Gelatinase-Associated Lipocalin as Markers of Oxidative Stress in Small for Gestational Age Newborns from Hypertensive and Preeclamptic Pregnancies

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