Perifolliculitis capitis abscedens et suffodiens (Hoffman). Complete healing associated with oral zinc therapy

Berne, B.

doi:10.1001/archderm.121.8.1028

Cited by 30 publications

(32 citation statements)

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“…Suboptimal dosing and inadequate treatment duration can result in an unsatisfactory outcome. 285,326,337,338 In isolated case reports, prolonged remission of disease for 1 year or more has been reported with isotretinoin gel (0.05%, used with 1% clindamycin gel for 8 weeks, followed by isotretinoin gel alone for 8 months, frequency not specified 339 ), zinc sulfate 326,340,341 (400 mg by mouth three times daily for 12 weeks, then 200 mg by mouth three times daily for 10 weeks 341 ), and oral steroids with low-dose alternate-day maintenance therapy. 323 Other options include oral and topical antibiotics (eg, tetracyclines, antistaphylococcal agents), antibacterial soaps and intralesional triamcinolone acetonide, which are variably effective when used as single agents or in combination 6,318,319,[322][323][324] ; dapsone, reportedly effective in severe, treatment-refractory disease (regimen unknown) by some 342 but not by others 285,343 ; and colchicine (0.6 g twice daily), which was moderately effective in 1 case.…”

Section: Perifolliculitis Capitis Abscedens Et Suffodiensmentioning

confidence: 99%

Update on primary cicatricial alopecias

Ross

Tan

Shapiro

2005

Journal of the American Academy of Dermatology

253

323

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Section: Perifolliculitis Capitis Abscedens Et Suffodiensmentioning

confidence: 99%

Update on primary cicatricial alopecias

Ross

Tan

Shapiro

2005

Journal of the American Academy of Dermatology

253

323

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“…Existing modalities of treatment including electrocautery, cryotherapy which involve destruction or removal of visible lesions do not prevent recurrences and may even result in scarring. Zinc, a non-toxic trace element which has been used as an immunomodulator in various dermatological ailments such as leg ulcers, erythema nodosum leprosum (type 2 reaction) and dissecting cellulitis of scalp, has been tried in viral warts with encouraging results [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Role of oral zinc sulphate in warts-a placebo controlled,single-blinded study

Hassan¹,

Bhat²,

Altaf³

et al. 2013

Our Dermatol Online

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Verrucae (synonym: warts) are one of the most common viral infections of humans in which the most frequently used modalities of treatment involve destruction of the affected area, which does not prevent recurrences and often results in scarring. In the present study oral zinc sulphate, an immunomodulator was evaluated as a treatment modality for warts. A placebo-controlled, single-blinded study was conducted on one hundred OPD patients with various types of verrucae. Fifty patients were put on oral zinc sulphate at dose of 5mg/kg for six weeks, while an equal number of patients received placebo for the same duration. In the patients who received oral zinc sulphate, 60.97% showed complete response at the end of six weeks in comparison to 6.45% partial response in the placebo group. The resolution of the lesions occurred with restoration of normal epidermal texture with transient alteration in pigmentation.

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“…However, treatment of the well-recognized relapsing nature of this disease becomes a clinical challenge. Recent literature has described successful treatment with systemic therapies including chronic oral zinc sulphate 3,13 and long-term isotretinoin. [10][11][12] Successful treatment of dissecting cellulitis has also been reported in the past with radiation therapy, although outdated equipment and techniques were employed.…”

Section: Discussionmentioning

confidence: 99%