Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis

Circulating IL17a and IFN-Gamma Serum Levels in Cirrhotic Hepatitis C Virus Infected Patients with Autoimmune Thyroiditis

“…This higher serum IL-17 in patients with chronic liver disease goes with what has been reported previously that serum IL-17 level was increased in liver injuries following chronic hepatitis and cirrhosis supporting a role for IL-17 as a chronic disease inducer in the pathogenesis and/or progression of liver fibrosis (Hassan et al, 2014).IL17 can activate a variety of immune cells to release inflammatory mediators which in turn lad to repeated inflammation of the liver (Harada et al, 2009). This could explain the strong positive correlation between IL17aserum level and ALT level (r = 0.3, P= 0.03) in our study.…”

Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease

“…Hepatocellular damage through IFN-␥ is thought to occur by a variety of mechanisms, including direct cellular injury, modulation of Ag presentation, and both the recruitment and activation of other immune cells (15,55). However, the immune phenotype of the cells that induce autoimmune chronic liver inflammation has come into question, with T H 17 immunity being observed as well (22,45 (37).…”

Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome

“…The former are known to be important in the prevention of autoimmune diseases by maintaining immunological self-tolerance and experimental studies in the RRV murine model of BA have shown that lack of Tregs in the first three days of life allows an unopposed viral infection to cause bile duct inflammation and occlusion (16). Th-17 cells, by contrast, have a destructive role in autoimmune biliary diseases such as primary biliary cirrhosis (17) and autoimmune hepatitis (18).…”