Periderm prevents pathological epithelial adhesions during embryogenesis

Richardson, Rebecca; Hammond, Nigel L.; Coulombe, Pierre A.; Saloranta, Carola; Nousiainen, Heidi; Salonen, Riitta; Berry, Andrew; Hanley, Neil A.; Headon, Denis J.; Karikoski, Riitta; Dixon, Michael J.

doi:10.1172/jci71946

Cited by 113 publications

(157 citation statements)

References 50 publications

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“…4Eii). In agreement with an earlier report (Richardson et al, 2014), upon epithelial stratification K17 expression became downregulated in the surface periderm cells, and the basal epithelial stem cells were P63 + and K17 + (Fig. 7Ai) and established a clear transition zone resembling that of a limbal margin.…”

Section: Lid and Corneal Surface Epithelial Margins In Developing Orgsupporting

confidence: 93%

“…The connecting periderm disintegrates and enables lid separation and eye opening during advanced stages of embryonic development in humans and at postnatal stages in rodents (Findlater et al, 1993;Huang et al, 2009). Unlike the developing skin periderm that is shed after birth (Richardson et al, 2014), the presence of K13 + K17 + K19 + periderm-like surface epithelium in developing MCs and in adult corneas suggests their probable role in normal ocular surface development and in adult tissue homeostasis. We hypothesize that this unique surface lining may help in preventing abnormal cell fusions between the corneal and lid surface epithelium during embryonic eye development and in wound repair processes during adult tissue regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…+ and K6 + (Richardson et al, 2014). During development, the periderm layer plays an important role in preventing pathological cell adhesions between the epithelial linings of adjacent organs, thus ensuring normal tissue formation.…”

Section: A Periderm Lining In Developing MC Structuresmentioning

confidence: 99%

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Generating minicorneal organoids from human induced pluripotent stem cells

et al. 2017

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Corneal epithelial stem cells residing within the annular limbal crypts regulate adult tissue homeostasis. Autologous limbal grafts and tissue engineered corneal epithelial cell sheets have been widely used in the treatment of various ocular surface defects. In case of bilateral limbal defects, pluripotent stem cell (PSC) derived corneal epithelial cells are now being explored as an alternative to allogeneic limbal grafts. We report here an efficient method to generate complex three dimensional corneal organoids from human PSCs. The eye field primordial (EFP) clusters that emerged from differentiating PSCs developed into whole eye ball-like, self-organized, three dimensional, miniature structures consisting of retinal primordia (RP), corneal primordia (CP), primitive eye lid-like outer covering and ciliary margin zone-like adnexal tissues in a step-wise maturation process within 15 weeks. These minicorneal organoids recapitulate the early developmental events in vitro and displayed similar anatomical features and marker expression profiles as that of adult corneal tissues and offers an alternative tissue source for regenerating different layers of the cornea and eliminates the need for complicated cell enrichment procedures.

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Section: Lid and Corneal Surface Epithelial Margins In Developing Orgsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Generating minicorneal organoids from human induced pluripotent stem cells

et al. 2017

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“…1). Recent data shows the critical presence of these periderm cells for proper craniofacial development, as animal models lacking the periderm exhibit oral adhesions and cleft palate (Casey et al, 2006; Richardson et al, 2009; Peyrard-Janvid et al, 2014; Richardson et al, 2014). About a day later, the tongue descends inferiorly as the mandibular arch lengthens to allow the paired palatal shelves to elevate and reorient from a vertical to a horizontal position and start to extend medially.…”

Section: Normal Embryological Developmentmentioning

confidence: 99%

“…Although its epidermal function is not fully understood, animal models lacking the periderm (i.e. Irf6 -, 14-3-3σ -, and Ikkα -deficient) exhibit altered epidermal terminal differentiation, suggesting a potential role for this structure in barrier formation (Richardson et al, 2014). …”

Section: Normal Embryological Developmentmentioning

confidence: 99%

Palatogenesis and cutaneous repair: A two‐headed coin

Biggs

Goudy

Dunnwald

2014

Developmental Dynamics

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The reparative mechanism that operates following post-natal cutaneous injury is a fundamental survival function that requires a well-orchestrated series of molecular and cellular events. At the end, the body will have closed the hole using processes like cellular proliferation, migration, differentiation and fusion. These processes are similar to those occurring during embryogenesis and tissue morphogenesis. Palatogenesis, the formation of the palate from two independent palatal shelves growing towards each other and fusing, intuitively, shares many similarities with the closure of a cutaneous wound from the two migrating epithelial fronts. In this review, we summarize the current information on cutaneous development, wound healing, palatogenesis and orofacial clefting and propose that orofacial clefting and wound healing are conserved processes that share common pathways and gene regulatory networks.

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Vertebrate Embryo: Development of the Skin and Its Appendages

Lei

Inaba

Chuong

2016

Encyclopedia of Life Sciences

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Vertebrate skin consists of epidermis and dermis, both of which are characterised as highly heterogeneous suborgan/tissues containing complex structures with diverse functions. Skin epidermis starts to stratify during embryogenesis. It plays pivotal barrier functions in protecting the organism from water loss and environmental insults during postnatal life. The dermis is a connective tissue that is separated with the epidermis by a deposition of extracellular matrix called the basement membrane. During skin development, many skin appendages are also induced. Those include epidermal appendages such as feather follicles, hair follicles, sebaceous glands and sweat glands and dermal appendages such as the arrector pili muscle. More and more stem cell populations are characterised in these appendages recently. In addition, considerable progress has been made in identifying molecules and pathways that regulate development and regeneration of skin and its appendages. Key Concepts During chick skin development, feathered areas are formed in the skin with high‐cell density of dermal cells and naked areas are formed in low‐cell density regions. Feather and hair development begins from thickening of epidermis and condensation of dermal cells, which is associated with the interaction among morphogens such as FGFs and BMPs. The mechanism by which feather buds are arranged in a periodic pattern on the skin and branching formation within each bud might be explained by reaction–diffusion model, one of the mathematical models. Feather follicles are differentiated from feather buds with the invaginated epidermis and the feathers have an ability of regeneration throughout lifetime owing to feather stem cells. Development and regeneration of hair follicle involve reciprocal epidermal and dermal cell interactions. Sequential activation of molecules including Wnt‐Eda‐Shh et al. is required for hair follicle development. Secondary hair germ cells first response, followed by bulge stem cell activation during hair regeneration. Regenerative hair cycling is regulated by epigenetic, microenvironment and macroenvironment factors.

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Periderm prevents pathological epithelial adhesions during embryogenesis

Cited by 113 publications

References 50 publications

Generating minicorneal organoids from human induced pluripotent stem cells

Generating minicorneal organoids from human induced pluripotent stem cells

Palatogenesis and cutaneous repair: A two‐headed coin

Vertebrate Embryo: Development of the Skin and Its Appendages

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