2022
DOI: 10.1161/atvbaha.121.317324
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Abstract: Background: Vascular pericytes stabilize blood vessels and contribute to their maturation, while playing other key roles in microvascular function. Nevertheless, relatively little is known about involvement of their precursors in the earliest stages of vascular development, specifically during vasculogenesis. Methods: We combined high-power, time-lapse imaging with transcriptional profiling of emerging pericytes and endothelial cells in r… Show more

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Cited by 16 publications
(17 citation statements)
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“…Intercellular communication has been investigated with a particular focus on cell–cell coupling between pericytes and endothelial precursor cells, which is a critically importance process during neovascular formation. This mechanism is associated with Cx43-based GJs, with a significant loss of neo-angiogenesis in a Cx43-depleted brain [ 132 ]. Notably, this phenomenon has not been reported in all subjects lacking Cx43-based GJs in pericytes [ 132 ].…”
Section: Connexins Signatures Of Nvu Componentsmentioning
confidence: 99%
See 1 more Smart Citation
“…Intercellular communication has been investigated with a particular focus on cell–cell coupling between pericytes and endothelial precursor cells, which is a critically importance process during neovascular formation. This mechanism is associated with Cx43-based GJs, with a significant loss of neo-angiogenesis in a Cx43-depleted brain [ 132 ]. Notably, this phenomenon has not been reported in all subjects lacking Cx43-based GJs in pericytes [ 132 ].…”
Section: Connexins Signatures Of Nvu Componentsmentioning
confidence: 99%
“…This mechanism is associated with Cx43-based GJs, with a significant loss of neo-angiogenesis in a Cx43-depleted brain [ 132 ]. Notably, this phenomenon has not been reported in all subjects lacking Cx43-based GJs in pericytes [ 132 ]. As such, it is likely that communication typically mediated by GJs still occurs via other Cxs, which compensates for the Cx43 loss.…”
Section: Connexins Signatures Of Nvu Componentsmentioning
confidence: 99%
“…These unique structures have been described as enriched for adherens junctions e.g. N-Cadherin (Gerhardt et al, 2000) and for gap junction localization to facilitate direct cellular communication (Diaz-Flores et al, 1991; Payne et al, 2022). Until recently, pericyte-derived “pegs” extending towards EC “sockets” were thought to be the predominant configuration (Zhao et al, 2015); however, EC pegs extending into PC sockets have also been described (Ornelas et al, 2021), and were observed in our datasets as well.…”
Section: Resultsmentioning
confidence: 99%
“…Nevertheless, it is widely accepted that the vBM between PCs and ECs thins and is likely absent at locations of direct PC-EC contact known as “peg-and-socket” junctions (Caruso et al, 2009; Diaz-Flores et al, 1991; Ornelas et al, 2021). These junctions are proposed to be domains for PC-EC coupling via gap junctions (Diaz-Flores et al, 1991; Payne et al, 2022) as well as adhesion protein localization (e.g. N-Cadherin) (Diaz-Flores et al, 2009; Fang et al, 2013; Gerhardt et al, 2000; Tillet et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Also, VEGFR2 blocking-mediated plaque stabilisation was accompanied by decreased VEGF and Ang-2 expression, while the expression of Connexin 40 and pericyte coverage of the capillary sprouts were increased [ 81 ]. Interestingly, other research showed that the related Connexin 43 is crucial for pericyte-EC communication during early vessel formation [ 82 ]. While different connexins may compensate each other, the correction of pericytes coverage via connexins level modulation may be a promising revascularisation/vascularisation strategy.…”
Section: Role Of Pericytes In Plaque Stabilisationmentioning
confidence: 99%