Perfusion CT imaging of treatment response in oncology

Perfusion parameters as potential imaging biomarkers for the early prediction of radiotherapy response in a rat tumor model

“…Computed tomography (CT) perfusion has been developed as a noninvasive in vivo imaging method to investigate tumor-associated vasculature, and it is increasingly used to monitor treatment response and quantify tumor vascularity in various solid cancers (9)(10)(11)(12)(13)(14). Its advantages include rapid scanning speed, high temporal and spatial resolution, and more importantly, routine availability; further, one of the greatest advantages of CT for perfusion imaging is the linear relationship between CT attenuation and iodine-based contrast concentration compared with other modalities, and this allows for an accurate absolute quantification of perfusion parameters (15).…”

An application study of low-dose computed tomography perfusion imaging for evaluation of the efficacy of neoadjuvant chemotherapy for advanced gastric adenocarcinoma

“…Nevertheless, low-resolution, highionization radiation doses and high cost issues have limited the widespread use of PET imaging in clinical practice. CT perfusion imaging is a new imaging modality that permits microcirculation evaluation and therefore can give insight into physiological information about the status of gastric perfusion [27]. In this study, we utilized lowdose spiral CT perfusion imaging to evaluate the efficacy of neoadjuvant chemotherapy in patients with advanced gastric adenocarcinoma and to determine whether any of the perfusion parameters would predict tumor response to chemotherapy.…”

Evaluation of splenic perfusion and spleen size using dynamic computed tomography: Usefulness in assessing degree of liver fibrosis

“…Our CT protocol was for preoperative evaluation of hepatic lesions and liver vascular anatomy as well as for perfusion analysis by a 64-row detector CT scanner, so the temporal resolution in our CT protocol was lower than in usual perfusion imaging. [19][20][21][22] However, it was high enough to evaluate the differences among patients with different stages of liver fibrosis. This is mainly because the pharmacokinetic model of the spleen is simpler than that of the liver for evaluating perfusion parameters, as explained above.…”