Performance of the Jouyban-Acree Model for Correlating the Solubility of Indomethacin and Ethylhexyl Triazone in Ethyl Acetate + Ethanol Mixtures

Abstract

This work reports the experimental volumetric properties and also the saturated solubility of indomethacin and ethylhexyl triazine in ethyl acetate + ethanol mixtures at 293.15 to 313.15 K and evaluates the validity of the Jouyban-Acree (J & A) model to correlate the solubility of these compounds in ethyl acetate + ethanol solvent mixtures. The solubility correlation is studied as a function of temperature and cosolvent composition. The J & A model requires only the experimental solubility values in the pure solvents at all the temperatures under study. The calculated values by using both compounds deviate as mean in 30% from experimental solubility values.

Measurements of Thermophysical Properties of Ethanol + Hexamethyldisiloxane and Ethanol + Octamethyltrisiloxane Mixtures in the Temperature Range of 293–343 K at 100 kPa

“…According to Rahimpour et al, Martinez et al, Khattab et al, and Arnautovic et al, the Jouyban-Acree model can be used to calculate the physicochemical properties of mixtures such as density, viscosity, and surface tension both for solute and solvent concentrations. Only the pure substance properties, concentrations, and three adjustable parameters are required, and the target variables can then be determined as a function of the temperature, according to ln nobreak0em.25em⁡ PCP mix ( T ) = w 1 · ln nobreak0em.25em⁡ PCP 1 ( T ) + w 2 · ln nobreak0em.25em⁡ PCP 2 ( T ) + w 1 w 2 · ∑ j = 0 2 [ A i j · ( w 1 − w 2 ) j T ] where PCP mix ( T ) is the physicochemical property (density, viscosity, and surface tension) of the mixture.…”