Performance of the COMPASS-31 questionnaire with regard to autonomic nervous system testing results and medication use: a prospective study in a real-life setting

Ruška, Berislav; Pavičić, Tin; Pavlović, Ivan; Junaković, Anamari; Adamec, Ivan; Crnošija, Luka; Skorić, Magdalena Krbot; Habek, Mario

doi:10.1007/s10072-018-3542-8

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…Since its publication in 2012, the original US English version of COMPASS 31 has been used in many studies [8][9][10][11][12][13] and proved to be a reliable and practical self-assessment Table 3 Comparison of total scores and sub-scores assessed with the original English and the German COMPASS 31 versions in 20 patients with neurological disorders and 20 healthy participants Data are expressed as mean ± standard deviation. P-values of the comparison between the English and German version scores are shown below the scores.…”

Section: Discussionmentioning

confidence: 99%

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Validation of the Composite Autonomic Symptom Score 31 in the German language

2021

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Background The Composite Autonomic Symptom Score 31 (COMPASS 31) is a validated, 31-item self-assessment questionnaire assessing autonomic symptoms in six domains, orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor function. So far, there is no validated German COMPASS 31 version. This study aimed at developing and validating a German COMPASS 31. Methods Two autonomic experts with command of German and English independently translated the English COMPASS 31 into German. One agreed-upon German version was translated back into English to assure conformity with the original version. Twenty patients with possible autonomic symptoms and 20 age- and gender-matched healthy persons completed the English and German COMPASS 31 in a randomized order with a 4-week interval. To evaluate reliability of the German COMPASS 31, total scores and sub-scores of the domains assessed with the German version were correlated with corresponding scores of the English version using Pearson’s or Spearman’s test. The Cronbach alpha-coefficient evaluated the internal consistency of the questions. Total- and sub-scores of both COMPASS 31 versions were compared between patients and controls by analysis of variance with post-hoc analysis (significance: p < 0.05). Results Total scores and sub-scores of the German and English COMPASS 31 correlated significantly (p < 0.001) and closely (correlation coefficients: 0.757–0.934). Cronbach alpha-coefficients were above 0.7 in all domains except for the secretomotor domain. In the German and English COMPASS 31, total scores were significantly higher in patients than controls. Conclusions The German COMPASS 31 is reliable, internally consistent, and valid to detect and quantify autonomic symptoms in patients with neurological disorders.

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Section: Discussionmentioning

confidence: 99%

“…Since its publication in 2012, the original US English version of COMPASS 31 has been used in many studies [ 8 – 13 ] and proved to be a reliable and practical self-assessment questionnaire to quantitatively evaluate the autonomic symptoms among patients with various neurological and other disorders [ 5 , 7 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Validation of the Composite Autonomic Symptom Score 31 in the German language

2021

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“…The sum of all the weighted domain scores yields a total COMPASS score between 0 and 100, representing minimum and maximum autonomic symptoms scores, respectively. The COMPASS‐31 has been shown to have excellent test–retest reliability, and internal validity, especially in the OI, vasomotor, gastrointestinal, and pupillomotor domains (Schultz et al, 2019 ; Treister et al, 2015 ) and has been validated in individuals with autonomic dysfunction (Ruška et al, 2018 ).…”

Section: Methodsmentioning

confidence: 99%

The prevalence and impact of orthostatic intolerance in young women across the hypermobility spectrum

Peebles

Tan

Butlin

et al. 2022

American J of Med Genetics Pt A

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Orthostatic intolerance (OI) is frequently reported in young women with generalized hypermobility spectrum disorder (G‐HSD) and hypermobile EDS (hEDS). However, it remains currently unclear whether OI is a comorbidity or fundamental part of the pathophysiology of G‐HSD or hEDS. This study investigated the prevalence and impact of OI in young women across the hypermobility spectrum. Forty‐five women (14–30 years, 15 controls, 15 G‐HSD, and 15 hEDS) undertook a head‐up tilt (HUT) and active stand test. Postural Orthostatic Tachycardia Syndrome (POTS) and Orthostatic Hypotension (OH) were assessed using age‐related criteria. Autonomic dysfunction and quality‐of‐life questionnaires were also completed. The prevalence of POTS was higher in women with G‐HSD than hEDS and control groups during HUT (43% vs. 7% and 7%, respectively, p < 0.05), but similar between groups during the active stand (47%, 27%, and 13% for G‐HSD, hEDS, and control, respectively). No participants had OH. hEDS and G‐HSD participants reported more severe orthostatic symptoms and poorer quality of life than controls. Although POTS was observed in hypermobile participants, there is no conclusive evidence that its prevalence differed between groups due to differences between the HUT and active stand assessments. Nevertheless, OI and broader autonomic dysfunction impacted on their quality of life.

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“…Literature suggests medians and ranges for healthy volunteers = 10 ± 8 (mean age 46.6 years), peripheral neuropathy = 21 ± 13 (mean age 59.5 years), and neurogenic autonomic failure = 39 ± 18 (mean age 57.4 years) ( 30 ). Several drugs have an influence on the autonomic nerve system, including beta blockers, ACE inhibitors, calcium channel blockers, alpha-1 blockers, and antihistamines ( 33 ).…”

Section: Methodsmentioning

confidence: 99%

Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life

et al. 2021

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Background: Autonomic symptoms are common in older adults, and a large body of literature focusing on age-related diseases shows that autonomic symptoms in these diseases constrain Health-Related Quality of Life (HRQoL). To our best knowledge, the association between autonomic symptoms in older adults, independent of specific diseases, and HRQoL has not yet been assessed.Aim: To assess the frequency and the effect of autonomic symptoms in general, as well as orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor symptoms, on HRQoL in older adults.Methods: Cross-sectional data of the fourth visit of the Tübinger evaluation of Risk factors for Early detection of Neurodegeneration (TREND) study were included. Autonomic symptoms, as assessed with the Composite Autonomic Symptom Score 31 (COMPASS 31), were quantified and compared with HRQoL, as assessed with the EuroQol five-level version (EQ-5D-5L). Statistical analyses included Spearman's rank correlation and multiple linear regression analysis.Results: The analysis included 928 participants with a median of 68 years; 47% were women. Of those, 85% reported at least one autonomic symptom. Gastrointestinal and secretomotor symptoms were most common. The COMPASS 31 total score and all subdomains were significantly associated with reduced HRQoL. Among the subdomains, the strongest correlations with HRQoL were found for gastrointestinal and bladder symptoms. Overall, autonomic symptoms alone explained 20% of the variance of HRQoL; when depressive mood was added, the model explained 32%.Conclusion: Autonomic symptoms are associated with HRQoL and depressive symptoms in older adults.

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Performance of the COMPASS-31 questionnaire with regard to autonomic nervous system testing results and medication use: a prospective study in a real-life setting

Cited by 18 publications

References 16 publications

Validation of the Composite Autonomic Symptom Score 31 in the German language

Validation of the Composite Autonomic Symptom Score 31 in the German language

The prevalence and impact of orthostatic intolerance in young women across the hypermobility spectrum

Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life

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