2002
DOI: 10.1097/00000542-200204000-00006
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Abstract: Bispectral Index, AAI, and predicted propofol effect-site concentration revealed information on the level of sedation and loss of consciousness but did not predict response to noxious stimulus.

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Cited by 199 publications
(43 citation statements)
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“…In addition, crossover midpoints and total dose of propofol in the control group were significantly higher and in proportion to the result; the BIS values in the nitrous oxide group were higher but there was no difference to the ratio of no-movement between the two groups. This supports previous reports [7] that depth-of-anaesthesia monitors are unable to predict movement in response to a noxious stimulus, and nitrous oxide does not affect the BIS index [8]. There have been two reports of Cp50 values for various noxious stimuli, Kazama et al [2] examined Cp50 values for propofol alone for tetanus shots, laryngoscopy, skin incision and tracheal intubation, as well as for loss of consciousness.…”
Section: Discussionsupporting
confidence: 73%
“…In addition, crossover midpoints and total dose of propofol in the control group were significantly higher and in proportion to the result; the BIS values in the nitrous oxide group were higher but there was no difference to the ratio of no-movement between the two groups. This supports previous reports [7] that depth-of-anaesthesia monitors are unable to predict movement in response to a noxious stimulus, and nitrous oxide does not affect the BIS index [8]. There have been two reports of Cp50 values for various noxious stimuli, Kazama et al [2] examined Cp50 values for propofol alone for tetanus shots, laryngoscopy, skin incision and tracheal intubation, as well as for loss of consciousness.…”
Section: Discussionsupporting
confidence: 73%
“…Haemodynamic variables are known to be poor indicators of the hypnotic state [16] and our study also shows similar results. The relation of haemodynamic variables to arousal was also not found to be consistent similar to findings by other researchers [17] [18] [19] [20]. Our study demonstrated that AEP reflected as the AAI scale is a valid tool for ascertaining the depth of anaesthesia and the AEP index is easy to calculate and all the calculations are real time.…”
Section: Discussionsupporting
confidence: 83%
“…Various commercial and noncommercial depth of anesthesia monitoring approaches have been developed (Kissin, 2000;Struys et al, 2002;Jordan et al, 2006;Ferenets et al, 2007;Liley et al, 2010;Shalbaf et al, 2013;Shoushtarian et al, 2015b,a) that primarily 5 rely on extraction of features from the EEG to track anesthetic brain state. Despite significant history and recent work attempting to characterise the mulit-channel EEG and brain networks related to anesthesia in more detail (Cimenser et al, 2011;Lewis et al, 2012;Purdon et al, 2013;Kuhlmann et al, 2013;Lee et al, 2013), the international uptake of automated depth of anesthesia monitoring in the clinic is still lagging.…”
Section: Introductionmentioning
confidence: 99%