2017
DOI: 10.1590/0074-02760160196
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Abstract: BACKGROUND In high tuberculosis (TB) burden countries, there are few data on the performance of new molecular commercialised assays developed locally.OBJECTIVE To evaluate the performance of a new molecular commercialised assay for TB diagnosis (Detect-TB) in three laboratories.METHODS A total of 302 sputum samples from an equal number of patients with presumptive diagnosis of pulmonary tuberculosis (PTB) were submitted for routine smear microscopy, culture, and Detect-TB assay at three different sites in Braz… Show more

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Cited by 3 publications
(3 citation statements)
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“…Xpert MTB/RIF), as well as the need for technicians trained in molecular techniques are limitations that pose considerable challenges, especially in low-resource settings. Despite significant advances in the development of novel tests, molecular tests cannot replace culture, but should be used in addition to conventional tests (smear microscopy, culture, and phenotypic drug susceptibility testing) and clinical data for TB diagnosis, as highlighted by other studies [ 115 , 116 ].…”
Section: Discussionmentioning
confidence: 99%
“…Xpert MTB/RIF), as well as the need for technicians trained in molecular techniques are limitations that pose considerable challenges, especially in low-resource settings. Despite significant advances in the development of novel tests, molecular tests cannot replace culture, but should be used in addition to conventional tests (smear microscopy, culture, and phenotypic drug susceptibility testing) and clinical data for TB diagnosis, as highlighted by other studies [ 115 , 116 ].…”
Section: Discussionmentioning
confidence: 99%
“… 5 The use of molecular techniques, besides contributing to detect the increase in the number of TB cases, also allows to quickly characterize resistance and define the existing genotypes in a given community. 6 …”
Section: Introductionmentioning
confidence: 99%
“…Resultados: Em relação aos testes de acurácia do Detect-TB, quando comparado aos resultados de microscopia e cultura, a sensibilidade e a especificidade foram 84,6% (IC 95%; 73,7-91,6) e 93,1% (IC 95%; 89,1-95,8), respectivamente. Quando comparado aos critérios bacteriológicos e clínicos, a sensibilidade e especificidade foram 74,3% (IC 95%; 63,3-82,9) e 92,9% (IC 95%; 88,7-95,6), respectivamente 8 . O Detect-TB mostrou ser custo-efetivo quando utilizado junto com a baciloscopia 9 .…”
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