Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts

Abstract

The study aimed to evaluate the tolerance, performance and effect on hair lipids and skin hydration of a protocol combining applications of one shampoo and subsequent mousses containing plant extracts (Ophytrium and Seboliance) in dogs with an undiagnosed chronic greasy keratinisation disorder. Six dogs were washed with plain water on day (D)0. Twelve dogs were shampooed on D0 and received eight mousse applications at 48–72 h intervals from D2 to D18. Clinical score (CS), Natural Moisturizing Factors (NMF) and hair lipids (HL) were evaluated on D0, D0 + 4 h, D7, D14 and D24. At baseline, no significant differences were observed in CS, NMF and HL between groups. In the control group, CS and HL remained stable throughout the study while a slight decrease in NMF was observed at D0 + 4 h. CS was significantly reduced in the test group between D0 and D7 (−53%) which reached 91% at D24 (p < 0.05), with no side effects. NMF levels decreased in the test group at D0 + 4 h (−73%, p < 0.0001) and returned to baseline from D14. In conclusion, one shampoo and subsequent mousse applications rapidly and safely improved coat quality in dogs with an undiagnosed keratinisation disorder without affecting NMF and HL contents over the study period.

Effects of a Protocol Combining a Non-Irritating Shampoo and an Adelmidrol-Based Adsorbent Mousse on Seborrhoea and Other Signs and Symptoms Secondary to Canine Atopic Dermatitis: A Multicenter, Open-Label Uncontrolled Clinical Trial

“…In a recent work [ 10 ], a keratomodulating mousse containing plant extracts ( Ophiopogon japonicus and Punica granatum ) proved capable of improving the clinical condition of seborrhoeic dogs; its application, once every two or three days for 24 days, decreased the scores of the same seborrhoea-related parameters investigated in this study (i.e., malodour, scaling, greasiness, and extension) in twelve untreated dogs affected by chronic, primary greasy keratinisation disorder.…”

“…This is in agreement with another study testing a topical protocol against greasy seborrhoea, as malodour seems to be the main complaint by the owners when keratinisation disorders occur, and one of the major reasons for shampooing their animals [ 62 ]. Also, shampooing probably helped remove some of the scales mechanically [ 10 ]. On the contrary, veterinarians scored higher points for evaluating the extent of the affected area, maybe because owners are less trained to quantify.…”

“…Topical products are used with the goal of keeping skin inflammation and infections better controlled, therefore decreasing or eliminating the need for systemic therapy. Shampoos were so far considered one of the most effective of the topical therapy options, yet their daily use is time-consuming, requires commitment, and eventually requires space and equipment [ 10 , 11 ] and overly frequent shampooing may be drying and irritating [ 1 ] due to the harsh effects of surfactants on the lipid composition of the skin barrier [ 10 , 12 ]. Over the past years, manufacturers have been working on easy-to-use formulations [ 10 ] in order to facilitate topical therapy by implementing easier protocols and to improve the quality of life of both cAD-affected dogs and their owners [ 13 , 14 ].…”

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“…The assessment of clinical signs in this study is adapted from Kondratjeva et al In their research, the authors employed a clinical score derived from four clinical parameters (malodour, scaling, greasiness, haircoat quality) and an additional extension score, utilising a 0 to 3 scale [21]. In our current study, we expanded upon this by incorporating six clinical parameters (including coat shining and coat softness) rated on a 0 to 4 scale, and removing the extension score.…”

“…On D0, D7 and D28, pet-owners evaluated pruritus (PVAS scale from 0-10) [20] and 6 individual clinical signs scaling, skin odour, skin greasiness, haircoat quality, coat softness on a 0-4 scale (0 = very good ; 4 = very bad) adapted from Kondrajteva [21]. The sum of individual scores was calculated to define a keratoseborrhoeic index (KSI).…”