Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: A pilot study

Ericson, Ingrid; Gómez, Mercedes; Nadal, Martí; Bavel, Bert van; Lindström, Gunilla; Domingo, José L.

doi:10.1016/j.envint.2007.01.003

Cited by 143 publications

(89 citation statements)

References 38 publications

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“…PFOSA and the telomere alcohols can be analyzed both by GC or LC. Good results have been obtained by GC/MS and GC/MS/MS [17 ] but also LC/MS [7]. It is currently unclear which technique will result in the best detection limits.…”

Section: Analytical Methodologymentioning

confidence: 62%

Accuracy and precision in the determination of perfluorinated chemicals in human blood verified by interlaboratory comparisons

Lindström

Kärrman

Bavel

2009

Journal of Chromatography A

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Perfluorinated chemicals, PFCs, are analyzed in laboratories worldwide to determine human blood levels and exposure pathways. The development of the analytical technique has been rapid in the last ten years, and prerequisites for accurate and precise determination of PFCs in human blood at low ng/g concentrations are today readily available. The main contributing factors are the improved LC-MS instrumentations, the increased availability of native and mass labeled PFC standards, and new column materials available for chromatographic separations. The results of the first international interlaboratory study (ILS) in 2005 on PFCs revealed relatively better analytical results for human blood analyses when compared to analyses of a number of environmental matrices. The representative accuracy for the analyses of PFCs in human matrixes reported in recent years was established in the second human serum ILS in 2006. Interlaboratory standard deviations for the two human serum samples one low level concentration and one medium level concentration were found to be 12% and 16% for PFOS, respectively, and 47% and 21% for PFOA, respectively. Reported detections for all PFCs followed a frequency of PFOS>PFOA>PFHxS>PFNA>PFDA>>PFDoA>> PFDS>>PFHxA. Due to the small number of reported values for the other perfluorosulfonates and perfluorocarboxylates, standard deviations were not established.

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Section: Analytical Methodologymentioning

confidence: 62%

Accuracy and precision in the determination of perfluorinated chemicals in human blood verified by interlaboratory comparisons

Lindström

Kärrman

Bavel

2009

Journal of Chromatography A

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“…PFOS and other PFSAs are widely distributed in the global environment [34][35][36][37][38], biota [39][40][41][42][43][44] and humans [15,[45][46][47][48][49][50][51][52]. Due to the dominance of POSF-based products historically, PFOS is usually the most abundant PFSA found.…”

Section: Perfluoroalkane Sulfonic Acids (Pfsas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

162

122

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Background: There is a concern that continued emissions of man-made per-and polyfluoroalkyl substances (PFASs) may cause environmental and human health effects. Now widespread in human populations and in the environment, several PFASs are also present in remote regions of the world, but the environmental transport and fate of PFASs are not well understood. Phasing out the manufacture of some types of PFASs started in 2000 and further regulatory and voluntary actions have followed. The objective of this review is to understand the effects of these actions on global scale PFAS concentrations.Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations were performed in bibliographic databases, on the internet, through stakeholder contacts and in review bibliographies. No time, document type, language or geographical constraints were applied in the searches. Relevant subjects included human and environmental samples. Two authors screened all retrieved articles. Dual screening of 10% of the articles was performed at title/abstract and full-text levels by all authors. Kappa tests were used to test consistency. Relevant articles were critically appraised by four reviewers, with double checking of 20% of the articles by a second reviewer. Meta-analysis of included temporal trends was considered but judged to not be appropriate. The trends were therefore discussed in a narrative synthesis.

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“…Bestalde, ionikoak diren PFAS-ak ur-sistemetan zehar hedatuz doaz eta beraien presentzia urrutiko lurraldetara hedatzen da. Azken urteotan giza odoletan [20][21][22][23] zein giza esnetan [24][25][26] aurkitutako PFAS mailak ikusita, kezka larria sortu da. Konposatu horiek gizakietara heltzeko dituzten bideetatik edateko ura [27,28], biota [29,30], janarien ontziratze-materialak [31,32] eta airea edo hautsa [33,34] dira aipagarrienak.…”

Section: Fluordun Konposatuak Gure Kostaldeko Bizidunetanunclassified

Fluordun konposatuak gure kostaldeko bizidunetan

Zabaleta¹,

Bilbao²,

Bizkarguenaga³

et al. 2017

EKAIA

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Laburpena: Egun, konposatu per-eta polifluoratuek (PFAS) gure eguneroko bizitzan dituzten erabilera anitzak direla-eta, ingurunean gero eta nabariagoa da euren presentzia. Ur-ekosistemen egoera aztertzea helburu, organismo itsastarrak kutsaduraren adierazle ezin hobeak dira. Ildo horretan, lan honetan Frantziako, Euskal Herriko, Espainiako eta Portugaleko kostaldeetako lazunen (Chelon labrosus) gibelak eta ostrak (Ostrea edulis) aztertu dira. Gibelen kasuan, azido perfluorooktanosulfonikoa (PFOS), azido perfluorodekanoikoa (PFDA) eta perfluorooktanosulfonamida (PFOSA) izan dira laginak biltzeko puntu guztietan detektatutako PFAS-ak. Aipatzekoa da Urdaibaiko Erreserba Naturalean kokatuta dagoen Gernikako itsasadarrean aurkitutako PFOS-aren kontzentrazioak (443-1.214 ng/g), araztegiaren edota industriaren eragina nabarmenduz. Ostren kasuan, PFOS-a eta PFOSA izan dira detektatutako kutsatzaileak, betiere gibelean lortutako kontzentrazioak baino baxuagoak. Hitz gakoak: Fluordun konposatuak, arrainen gibelak, ostrak.Abstract: Nowadays, due to the wide range of applications, the presence of per-and polyfluoroalkyl substances is increasing in the environment. Aquatic organisms are very useful bioindicators in order to assess the health of the aquatic environment. Within this objective, grey mullet (Chelon Labrosus) livers and oysters (Ostrea edulis) of the French, Basque, Spanish and Portuguese coasts were analysed. In the case of the liver, perfluorooctane sulfonic acid (PFOS), perfluorodecanoic acid (PFDA) and perfluorooctane sulfonamide (PFOSA) were the detected target analytes in all the sampling points. Surprisingly high concentrations of PFOS (443-1,214 ng/g) were detected in the river of Gernika, which is placed in the Natural Reserve of Urdaibai, highlight-

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Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: A pilot study

Cited by 143 publications

References 38 publications

Accuracy and precision in the determination of perfluorinated chemicals in human blood verified by interlaboratory comparisons

Accuracy and precision in the determination of perfluorinated chemicals in human blood verified by interlaboratory comparisons

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Fluordun konposatuak gure kostaldeko bizidunetan

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