Perfil hematológico e avaliação eletroforética das proteínas séricas de cães com cinomose

Silva, I.N.G.; Guedes, Maria Izabel Florindo; Rocha, Marcos F.G.; Oliveira, Luanna Castro; Moreira, Odanir Cruz; Teixeira, María Francisca Simas

doi:10.1590/s0102-09352005000100019

Cited by 14 publications

(27 citation statements)

References 7 publications

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“…According to McCandlish (2001), the clinical signs of CDV infection are variable and can be influenced by intrinsic and extrinsic factors such as age, physical condition, immune status, and the strain of virus involved. Regarding blood parameters, previous studies have reported the presence of normocytic normochromic anemia (Mendonça et al, 2000), leukocytosis or leukopenia, and lymphopenia (Silva et al, 2005). The present data are consistent with normocytic normochromic anemia and neutrophilia in the early stages of treatment, and lymphopenia.…”

Section: Discussionsupporting

confidence: 91%

Controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease

Pinheiro¹,

Cardoso²,

Vidane³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Distemper disease is an infectious disease reported in several species of domestic and wild carnivores. The high mortality rate of animals infected with canine distemper virus (CDV) treated with currently available therapies has driven the study of new efficacious treatments. Mesenchymal stem cell (MSC)-based therapy is a promising therapeutic option for many degenerative, hereditary, and inflammatory diseases. Therefore, the aim of this study was to characterize stem cells derived from the canine fetal olfactory epithelium and to assess the systemic response of animals infected with CDV to symptomatic therapy and treatment with MSCs. Eight domestic mongrel dogs (N = 8) were divided into two groups: support group (SG) (N = 5) and support group + cell therapy (SGCT) (N = 3), which were monitored over 15 days. Blood samples were collected on days 0, 6, 9, 12, and 15 to assess blood count and serum biochemistry (urea, creatinine, alanine transferase, alkaline phosphatase, gammaglutamyl transferase, total protein, albumin, and globulin), and urine samples were obtained on days 0 and 15 for urinary evaluation (urine I). The results showed a high mortality rate (SG = 4 and SGCT = 2), providing inadequate data on the clinical course of CDV infection. MSC therapy resulted in no significant improvement when administered during the acute phase of canine distemper disease, and a prevalence of animals with high mortality rate was found in both groups due to the severity of symptoms.

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Section: Discussionsupporting

confidence: 91%

Controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease

Pinheiro¹,

Cardoso²,

Vidane³

et al. 2016

Genet. Mol. Res.

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show abstract

“…Segundo Greene et al (1993) e Jain and Jain (1993), a linfopenia, monocitose e neutrofilia ocorrerão quando o quadro clínico já estiver instalado. Na contagem total de plaquetas verificou-se que 35,8% dos animais apresentavam trombocitopenia, o que concorda com Silva et al (2005). Esses mesmos autores, sugerem que esta alteração decorre por um processo imunomediado com retirada das plaquetas da circulação pelos macrófagos.…”

Section: Resultsunclassified

Parámetros hematológicos de perros presentando corpúsculos de Lentz en frotis sanguíneo

Silva

Araújo

Leite

et al. 2017

Pubvet

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“…Na contagem total de plaquetas tivemos onze (36,7%) animais com trombocitopenia, o que corrobora com Silva et al (2005) ao sugeririam que isto ocorre por um processo imunomediado com retirada das plaquetas da circulação, através dos macrófagos. E apenas um animal com trombocitose.…”

Section: Resultado E Discussãounclassified

“…Altamente contagiosa, a cinomose canina é considerada uma doença com alta taxa de letalidade, quando comparada a outras doenças infectocontagiosas em cães [Silva et al 2005;Gebara et al 2004]. Ademais, esta doença tem sido considerada reemergente em países onde já esteve controlada [Norris et al 2006].…”

Section: Introductionunclassified

Perfil Hematológico em Cães Infectados Naturalmente por Cinomose com Presença de Corpúsculo de Sinegaglia Lentz, em Vassouras - RJ

2016

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Em trinta cães atendidos no Hospital Veterinário da Universidade Severino Sombra, com sinais clínicos e corpúsculos de inclusão de Sinegaglia Lentz em células sanguíneas, foram observadas as alterações hematológicas de anemia (80%); leucocitose (13,3%); leucopenia (10%); DNNE (33,3%); neutrofilia (46,7%); linfopenia (46,7%); linfocitose (6,7%); monocitose (13,3%) e trombocitopenia (36,7%). Além disso, observamos que 66,7% dos casos foram atendidos no verã; 80% dos animais tinham apenas infecções secundárias no primeiro atendimento; 41% dos cães não tinham raça definida (SRD) e 86,7 % dos animais tinham corpúsculo de inclusão vírica em linfócitos.

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Perfil hematológico e avaliação eletroforética das proteínas séricas de cães com cinomose

Cited by 14 publications

References 7 publications

Controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease

Controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease

Parámetros hematológicos de perros presentando corpúsculos de Lentz en frotis sanguíneo

Perfil Hematológico em Cães Infectados Naturalmente por Cinomose com Presença de Corpúsculo de Sinegaglia Lentz, em Vassouras - RJ

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