Perfil bioquímico sanguíneo na intoxicação experimental com extrato de Mascagnia rigida (A. Juss.) Griseb. (Malpighiaceae) em coelhos

Abstract

Avaliou-se o perfil bioquímico sanguíneo na intoxicação por Mascagnia rigida, uma planta tóxica que gera problema econômico para a pecuária, por causar morte súbita. Nove coelhos Nova Zelândia, machos, com massa corporal média de 3,54kg, foram distribuídos em três grupos (G) (n=3). Os animais receberam, durante oito dias consecutivos, o equivalente a 30g/kg de matéria seca da planta em dois tipos de extratos: solúvel em água (GS) e insolúvel em água (GI), e formou-se também o grupo-controle (GC). Os exames bioquímicos foram realizados previamente ao início do experimento até o nono dia. A administração dos extratos da Mascagnia rigida causou alterações eletrolíticas que podem justificar alguns sinais clínicos observados e atuar de forma significativa na causa mortis.

Resistance transferance of Amorimia septentrionalis poisoning in goats by ruminal transferance fluid from goats with induced resistance by the inoculation of sodium monofluoroacetate-degrading bacteria

“…The decrease of serum calcium and the increase of serum phosphorus observed in the poisoned goats were also observed by PEREIRA et al (1996) and BORBOLETA et al (2011), who suggested that the changes in the homeostasis of these elements is due to the action of the MFA. According to BORBOLETA et al (2011), the disturbances in these electrolytes may destabilize the resting potential of cell membranes affecting several metabolic pathways dependent on these ions.…”

“…According to BORBOLETA et al (2011), the disturbances in these electrolytes may destabilize the resting potential of cell membranes affecting several metabolic pathways dependent on these ions. In the Krebs cycle, the MFA present in A. septentrionalis is transformed into fluorocitrate, and during this process, there is a drop in ATP production, which leads to blocking a series of energy-dependent metabolic processes (CLARKE, 1991) that can destabilize calcium and phosphorus homeostasis.…”

Taxonomic revision of Amorimia W.R. Anderson (Malpighiaceae)

“…As a result, a couple of species (e.g., A. rigida and A. maritima; commonly referred either as A. rigida or A. aff. rigida) have been usually considered as responsible for bovine sudden death in different parts of the country (Tokarnia et al 1961, 1990, 1994, 1996, Tokarnia & Döbereiner 1973, 1985, Medeiros et al 2002, Silva et al 2006, Melo et al 2008, Vasconcelos et al 2008, Assis et al 2009, Garcez et al 2009, Lago et al 2009, Borboleta et al 2011, Nogueira et al 2011, Schons et al 2011, Lee et al 2012, Becker et al 2013, Duarte et al 2013, Neto et al 2013, Pessoa et al 2013, Barros & Meneguetti 2014 et al 2017). Recently, broad phytochemical studies have identified monofluoracetate as the compound responsible for Amorimia's toxicity to mammals (Lee et al 2012).…”

Metabolic Profile of Goats Fed Diets Containing Crude Glycerin from Biodiesel Production

“…The creatine kinase myocardial isoenzyme (CK-MB) is an isoenzyme found mainly in the heart and whose quanti cation can be applied reliably in diagnosing acute myocardial infarction in humans. The enzyme has been well-studied in rodents [25,26] but is not entirely reliable in eld evaluations because of its short half-life [27]. Notwithstanding, [28] found altered CK-MB values in cattle intoxicated by Nerium oleander, most commonly known as oleander, whose ingestion by animals leads to several clinical symptoms such as arrhythmia, paralysis, and even death.…”