2020
DOI: 10.1172/jci.insight.131487
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Abstract: Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses-ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation-are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep an… Show more

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Cited by 142 publications
(122 citation statements)
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References 154 publications
(166 reference statements)
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“…Concerning the second basis of chronotherapy, it should be stressed that the immune system displays very strong circadian rhythmicity [54]. At the beginning of daily activity, there is increased expression of pro-inflammatory mediators such as interleukin (IL)-1β, IL-6, and IL-12, as well as macrophage and leukocyte activity, which leads to potential damage to tissues.…”
Section: Chronotherapymentioning
confidence: 99%
“…Concerning the second basis of chronotherapy, it should be stressed that the immune system displays very strong circadian rhythmicity [54]. At the beginning of daily activity, there is increased expression of pro-inflammatory mediators such as interleukin (IL)-1β, IL-6, and IL-12, as well as macrophage and leukocyte activity, which leads to potential damage to tissues.…”
Section: Chronotherapymentioning
confidence: 99%
“…Disruption of the circadian clock system and sleep plays a critical role in immune system homeostasis ( Castanon-Cervantes et al, 2010 ). Innate and adaptive immune responses are regulated in a time of day-dependent manner ( Haspel et al, 2020 ) Melatonin, a potent antioxidant, is known to have pleiotropic effects on the immune system ( Carrillo-Vico et al, 2013 ). Glutamate’s inhibitory effect on melatonin synthesis involves interactions between astrocytes and pinealocytes, through the release of astrocytic TNF-alpha, a potent mediator of inflammation ( Villela et al, 2013 ).…”
Section: Main Articlementioning
confidence: 99%
“…In both genders waist circumference has been reported to have a tight association with sleep disturbance [18]. This is because visceral adipose tissue is the main source of pro-in ammatory cytokines, such as interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α that, beyond chronic low-grade in ammation [19,20], could have a role in sleep regulation such that they are called 'sleep-regulatory substances' [21,22]. Quarantine was also associated with a change of working modalities in most of the people.…”
Section: Introductionmentioning
confidence: 99%