Percutaneous cryoablation of adrenal metastases: technical feasibility and safety

Aoun, Hussein D.; Littrup, Peter J.; Nahab, Bashar; Rizk, Michael; Prus, M.; Samantray, Julie; Weaver, Donald W.; Vaishampayan, Ulka N.; Pontes, Edson

doi:10.1007/s00261-020-02848-1

Cited by 7 publications

(16 citation statements)

References 34 publications

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“…The study selection process is detailed in Figure 1 . In total, 15 articles were included in this meta-analysis [ 12 – 26 ], all of which were retrospective ( Table I ). These studies included 538 patients with 562 AMs who underwent treatment via imaging-guided PA. Of these 15 articles, 8 employed radiofrequency ablation (RFA) [ 14 – 16 , 18 , 20 , 22 , 25 , 26 ], 5 employed cryoablation (CA) [ 12 , 13 , 17 , 23 , 24 ], and 2 employed microwave ablation (MWA) [ 19 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…These studies included 538 patients with 562 AMs who underwent treatment via imaging-guided PA. Of these 15 articles, 8 employed radiofrequency ablation (RFA) [ 14 – 16 , 18 , 20 , 22 , 25 , 26 ], 5 employed cryoablation (CA) [ 12 , 13 , 17 , 23 , 24 ], and 2 employed microwave ablation (MWA) [ 19 , 21 ]. In addition, 10 studies employed CT guidance [ 12 , 13 , 15 , 19 , 20 , 22 – 26 ], while 5 employed US guidance [ 14 , 16 – 18 , 21 ]. Of these studies, 9 included patients with multiple primary cancers [ 12 , 14 , 15 , 17 , 18 , 21 , 23 , 25 , 26 ], while 3 included patients with AMs secondary to lung cancer (LC) [ 13 , 19 , 24 ], and 3 studies enrolled individuals with AMs secondary to hepatocellular carcinoma (HCC) [ 16 , 20 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…In total, 15 articles were included in this meta-analysis [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], all of which were retrospective (Table I). These studies included 538 patients with 562 AMs who underwent treatment via imaging-guided PA. Of these 15 articles, 8 employed radiofrequency ablation (RFA) [14-16, 18, 20, 22, 25, 26], 5 employed cryoablation (CA) [12,13,17,23,24], and 2 employed microwave ablation (MWA) [19,21]. In addition, 10 studies employed CT guidance [12,13,15,19,20,[22][23][24][25][26], while 5 employed US guidance [14,[16][17][18]21].…”

Section: Study Selectionmentioning

confidence: 99%

“…In addition, 10 studies employed CT guidance [12,13,15,19,20,[22][23][24][25][26], while 5 employed US guidance [14,[16][17][18]21]. Of these studies, 9 included patients with multiple primary cancers [12,14,15,17,18,21,23,25,26], while 3 included patients with AMs secondary to lung cancer (LC) [13,19,24], and 3 studies enrolled individuals with AMs secondary to hepatocellular carcinoma (HCC) [16,20,22]. All articles reported NOS scores in the range 7-8.…”

Section: Study Selectionmentioning

confidence: 99%

“…Local recurrence rates were reported in 12 studies [12,13,[15][16][17][18][19][22][23][24][25][26], with a pooled local recurrence rate of 19% (95% CI: 0.15-0.23, Figure 2 F). This endpoint was associated with low levels of heterogeneity (I 2 = 0%, p = 0.87), as well as a low risk of publication bias (Egger's test: p = 0.744).…”

Section: Local Recurrencementioning

confidence: 99%

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Percutaneous ablation for adrenal metastases: a systematic review and meta-analysis.

Zhang¹,

Fu²,

Wang³

2022

Videosurgery and Other Miniinvasive Techniques

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Introduction: Imaging-guided percutaneous ablation (PA) is commonly employed for the treatment of patients diagnosed with adrenal metastasis (AM), but comprehensive analyses are essential to validate the efficacy and safety of this approach. Aim: The present meta-analysis was designed to evaluate the safety, efficacy, and long-term outcomes associated with the imaging-guided PA treatment of AM. Material and methods: Relevant studies in the PubMed, Embase, and Wanfang databases published as of June 2022 were identified, and pooled endpoint analyses were performed with Stata 12.0. Results: This meta-analysis included 15 studies. Overall, the respective pooled primary technical success, secondary technical success, local hemorrhage, pneumothorax, hypertension crisis, local recurrence, 1-year overall survival (OS), and 3-year OS rates in study participants were 88%, 93%, 3%, 6%, 6%, 19%, 80%, and 46%. High levels of heterogeneity were evident for the 1-year OS (I 2 = 79.6%) and 3-year OS endpoints (I 2 = 67.1%), but meta-regression analyses failed to identify predictors of these OS rates. Low heterogeneity was observed for subgroups of patients who had undergone cryoablation (I 2 = 0%) or patients with multiple primary cancers (I 2 = 0%) with respect to 1-year OS. Similarly, low heterogeneity for the 3-year OS endpoint was detected in subgroups of patients who had undergone cryoablation (I 2 = 0%), ultrasound-guided PA (I 2 = 0%), individuals with AMs secondary to hepatocellular carcinoma (I 2 = 0%), and patients with multiple primary cancers (I 2 = 0%).Conclusions: These results suggest imaging-guided PA to be a safe and effective treatment for AM associated with satisfactory long-term patient outcomes.

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