Perceptual deficits in amnesia: challenging the medial temporal lobe ‘mnemonic’ view

Lee, Andy; Bussey, Timothy J.; Murray, Elisabeth A.; Saksida, Lisa M.; Epstein, Russell A.; Kapur, Narinder; Hodges, John R.; Graham, Kim S.

doi:10.1016/j.neuropsychologia.2004.07.017

Cited by 295 publications

(375 citation statements)

References 33 publications

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“…Interestingly, the performance of MTL-damaged patients deviated from control performance in two ways: first, they reported seeing the Familiar Configurations as figure somewhat less often than controls, and second, they reported seeing the Part-Rearranged Novel Configurations as figure more often than controls. Taken alone, the first finding is consistent with the theoretical view that the PRC of the MTL contains representations of complex configurations Lee et al, 2005;Barense et al, 2005Barense et al, , 2007Barense et al, , 2010a; Bartko et al, 2007;Lee and Rudebeck, 2010;Burke et al, 2011), and damage to these configural representations removes effects of configuration familiarity on figure assignment. Taken together, however, the two findings suggest that either output from the PRC is privileged over that from lower-level visual regions during figure-ground assignment (a feedforward explanation for the data) or that the intact PRC plays a role in modulating processing in lower-level visual areas (a feedback explanation).…”

Section: Introductionsupporting

confidence: 81%

The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

Peterson¹,

Cacciamani²,

Barense³

et al. 2012

Hippocampus

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ABSTRACT:Research has demonstrated that the perirhinal cortex (PRC) represents complex object-level feature configurations, and participates in familiarity versus novelty discrimination. Barense et al. [(in press) Cerebral Cortex, 22:11, doi:10.1093/cercor/bhr347] postulated that, in addition, the PRC modulates part familiarity responses in lower-level visual areas. We used fMRI to measure activation in the PRC and V2 in response to silhouettes presented peripherally while participants maintained central fixation and performed an object recognition task. There were three types of silhouettes: Familiar Configurations portrayed realworld objects; Part-Rearranged Novel Configurations created by spatially rearranging the parts of the familiar configurations; and Control Novel Configurations in which both the configuration and the ensemble of parts comprising it were novel. For right visual field (RVF) presentation, BOLD responses revealed a significant linear trend in bilateral BA 35 of the PRC (highest activation for Familiar Configurations, lowest for Part-Rearranged Novel Configurations, with Control Novel Configurations in between). For left visual field (LVF) presentation, a significant linear trend was found in a different area (bilateral BA 38, temporal pole) in the opposite direction (Part-Rearranged Novel Configurations highest, Familiar Configurations lowest). These data confirm that the PRC is sensitive to the agreement in familiarity between the configuration level and the part level. As predicted, V2 activation mimicked that of the PRC: for RVF presentation, activity in V2 was significantly higher in the left hemisphere for Familiar Configurations than for Part-Rearranged Novel Configurations, and for LVF presentation, the opposite effect was found in right hemisphere V2. We attribute these patterns in V2 to feedback from the PRC because receptive fields in V2 encompass parts but not configurations. These results reveal two new aspects of PRC function: (1) it is sensitive to the congruency between the familiarity of object configurations and the parts comprising those configurations and (2) it likely modulates familiarity responses in visual area V2. V V C 2012 Wiley Periodicals, Inc.

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Section: Introductionsupporting

confidence: 81%

The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

Peterson¹,

Cacciamani²,

Barense³

et al. 2012

Hippocampus

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“…Here, too, we localised HC using a working memory task, thus complementing previous studies that find evidence for HC recruitment across a range of cognitive tasks. Indeed, several studies of patients with HC atrophy have reported scene‐specific deficits for both memory and perceptual tasks [Bird et al, 2008; Hartley et al, 2007; Lee et al, 2005a, 2005b; Mullally et al, 2012; but see Kim et al, 2011, 2015]. Functional neuroimaging studies have likewise found group‐level HC activation during scene discrimination [Aly et al, 2013; Lee et al, 2008], scene construction/imagining [Zeidman et al, 2015], and working memory [Lee and Rudebeck, 2010b; Park et al, 2003].…”

Section: Discussionmentioning

confidence: 99%

“…Beyond the seminal work in both rats and non‐human primates—which identified HC cells attuned to allocentric location [O'Keefe and Nadel, 1978] and spatial view [Rolls, 1999]—recent models of human medial temporal lobe (MTL) function highlight the HC as an important structure for scene processing, via a proposed role in representing complex and conjunctive scene stimuli [Graham et al, 2010; Lee et al, 2012; Murray et al, 2007] and/or by contributions to viewpoint‐independent scene construction [Bird and Burgess, 2008; Maguire and Mullally, 2013; Zeidman et al, 2015]. These complex HC scene representations have been shown to support behavioural performance across a range of cognitive domains, including recognition memory [Bird et al, 2008; Taylor et al, 2007], short‐term memory [Hannula et al, 2006; Hartley et al, 2007], working memory [Lee and Rudebeck, 2010a, 2010b; Park et al, 2003], perceptual learning [Mundy et al, 2013], higher‐order perception [Aly et al, 2013; Barense et al, 2005, 2010; Kolarik et al, 2016; Lee et al, 2005b] and scene imagination [Hassabis et al, 2007]. …”

Section: Introductionmentioning

confidence: 99%

Evidencing a place for the hippocampus within the core scene processing network

Hodgetts

Shine

Lawrence

et al. 2016

Human Brain Mapping

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Functional neuroimaging studies have identified several “core” brain regions that are preferentially activated by scene stimuli, namely posterior parahippocampal gyrus (PHG), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS). The hippocampus (HC), too, is thought to play a key role in scene processing, although no study has yet investigated scene‐sensitivity in the HC relative to these other “core” regions. Here, we characterised the frequency and consistency of individual scene‐preferential responses within these regions by analysing a large dataset (n = 51) in which participants performed a one‐back working memory task for scenes, objects, and scrambled objects. An unbiased approach was adopted by applying independently‐defined anatomical ROIs to individual‐level functional data across different voxel‐wise thresholds and spatial filters. It was found that the majority of subjects had preferential scene clusters in PHG (max = 100% of participants), RSC (max = 76%), and TOS (max = 94%). A comparable number of individuals also possessed significant scene‐related clusters within their individually defined HC ROIs (max = 88%), evidencing a HC contribution to scene processing. While probabilistic overlap maps of individual clusters showed that overlap “peaks” were close to those identified in group‐level analyses (particularly for TOS and HC), inter‐individual consistency varied across regions and statistical thresholds. The inter‐regional and inter‐individual variability revealed by these analyses has implications for how scene‐sensitive cortex is localised and interrogated in functional neuroimaging studies, particularly in medial temporal lobe regions, such as the HC. Hum Brain Mapp 37:3779–3794, 2016. © 2016 Wiley Periodicals, Inc.

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“…In the perceptual-mnemonic/ feature-conjunction (PMFC) model, an argument is made using evidence from non-human primate (Bussey et al, 2003 and human studies (Lee et al, 2005) that the perirhinal cortex becomes involved in perception when the perceptual load increases. They suggest that in this capacity the perirhinal cortex acts as part of the ventral visual stream in addition to being part of the medial temporal lobe as it is traditionally classified.…”

Section: The Perirhinal Cortex and Perceptionmentioning

confidence: 99%

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Kealy

Commins

2011

Progress in Neurobiology

105

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Perceptual deficits in amnesia: challenging the medial temporal lobe ‘mnemonic’ view

Cited by 295 publications

References 33 publications

The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

The perirhinal cortex modulates V2 activity in response to the agreement between part familiarity and configuration familiarity

Evidencing a place for the hippocampus within the core scene processing network

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

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