2013
DOI: 10.1387/ijdb.130132fb
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Abstract: Germ cell development is a step-wise process that ensures the progression of the life cycle due to their unique ability to transmit their genome from one generation to the next. In the mouse, the precursors of germ cells, the Primordial Germ Cells (PGCs), arise at the onset of gastrulation. Here we discuss how PGCs acquire their fate in the epiblast and outline their development until their arrival into the gonads. Male germ cell tumors (GCTs) have a similar gene expression pattern to that of fetal germ cells … Show more

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Cited by 4 publications
(5 citation statements)
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References 72 publications
(93 reference statements)
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“…Mouse is the primary model organism for early mammalian development, pluripotency and the regulation of cell fates. Post-implantation rodent embryos develop as egg cylinders with an overlying extraembryonic ectoderm, which is the source of signals, including BMP4, while postimplantation epiblast embryonic disc in humans is typical of many mammalian species (Barrios et al, 2013; De Fellici, 2013; Irie et al, 2014). These differences may affect the source, duration and the nature of signalling molecules that regulate competence for cell fates in vivo .…”
Section: Discussionmentioning
confidence: 99%
“…Mouse is the primary model organism for early mammalian development, pluripotency and the regulation of cell fates. Post-implantation rodent embryos develop as egg cylinders with an overlying extraembryonic ectoderm, which is the source of signals, including BMP4, while postimplantation epiblast embryonic disc in humans is typical of many mammalian species (Barrios et al, 2013; De Fellici, 2013; Irie et al, 2014). These differences may affect the source, duration and the nature of signalling molecules that regulate competence for cell fates in vivo .…”
Section: Discussionmentioning
confidence: 99%
“…In mammals, germ-line formation occurs in the early embryo when a small number of PGCs is specified among embryonic cells with a somatic fate (16). This type of determination of the germ line, referred to as inductive determination, is thought to be the most ancient mechanism for germ-line formation in animals (17).…”
Section: Bp) (C and D)mentioning
confidence: 99%
“…The gametocytogenesis of Plasmodium parasites appears to be of this type, because only a small number of blood-stage parasites, most of which repeatedly enter an asexual proliferation cycle, will become gametocytes. In mice, a stage-specific transcriptional repressor (B lymphocyteinduced maturation protein 1, BLIMP1) is expressed as a master regulator (12,16) and distinguishes the precursors of PGCs from the somatic lineage by repressing genes for somatic differentiation, such as Hox genes. The generated PGCs migrate to the developing gonads, where they differentiate into female or male gametes (oocytes and spermatocytes).…”
Section: Bp) (C and D)mentioning
confidence: 99%
“…The process is similar in both sexes and regulated by a complex network of pre-programmed genes regulated by epigenetic events, including erasure of imprinting [14][15][16]. PGCs migrate towards genital ridges, starting from 3-4 weeks of gestation (GW) and reach the ridges around the fifth GW [17][18].…”
Section: Development and Sex Differentiation Of Human Fetal Gonadsmentioning
confidence: 99%