2003
DOI: 10.1074/jbc.m302757200 View full text |Buy / Rent full text
|
|

Abstract: The transporter associated with antigen processing (TAP) plays a key role in the adaptive immune response by pumping antigenic peptides into the endoplasmic reticulum for subsequent loading of major histocompatibility complex class I molecules. TAP is a heterodimer consisting of TAP1 and TAP2. Each subunit is composed of a transmembrane domain and a nucleotide-binding domain, which energizes the peptide transport. To analyze ATP hydrolysis of each subunit we developed a method of trapping 8-azido-nucleotides t… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
4
70
1
2

Publication Types

Select...

Relationship

0
0

Authors

Journals