Peptides from sea cucumber intestine: Preparation and promoting cartilage callus formation in mice with tibial fractures by promoting the polarization of M1 to M2 macrophages

Yin, Haowen; Hao, Ya; Wang, Meng C.; Tian, Yingying; Zhang, Tianqi; Zhao, Zifang; Liu, Hongying; Wang, Jingfeng; Xue, Changhu

doi:10.1016/j.jff.2023.105718

Cited by 1 publication

(1 citation statement)

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“…[132] A peptide, SCIP, promotes the polarization of macrophages from M1 to M2 and promotes the formation of callus after fracture. [97] A. japonicus polysaccharides and peptides can all be used as functional foods or nutritional supplements to prevent osteoporosis and promote fracture recovery. BMP-2 has the potential to regulate important skeletal development processes as a target in the BMP/ MAPK pathway.…”

Section: Effects On Bonementioning

confidence: 99%

Chemical substances and their activities in sea cucumber Apostichopus japonicus: A review

Lu,

Wang,

et al. 2023

Archiv der Pharmazie

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Apostichopus japonicus, also known as Stichopus japonicus, with medicinal and food homologous figures, is a globally recognized precious ingredient with extremely high nutritional value. There is no relevant review available through literature search, so this article selects the research articles through the keywords “sea cucumber” and “Apostichopus japonicus (Stichopus japonicus)” in six professional databases, such as Wiley, PubMed, ScienceDirect, ACS, Springer, and Web of Science, from 2000 to the present, summarizing the extraction, isolation, and purification methods for the four major categories (polysaccharides, proteins and peptides, saponins, and other components) of the A. japonicus chemical substances and 10 effective biological activities of A. japonicus. Included are anticoagulation, anticancer/antitumor activities, hematopoiesis, regulation of gut microbiota, and immune regulatory activities that correspond to traditional efficacy. Literature support is provided for the development of medicines and functional foods and related aspects that play a leading role in future directions.

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Section: Effects On Bonementioning

confidence: 99%