Peptide generated anisotropic gold nanoparticles as efficient siRNA vectors

Panigrahi, Bijayananda; Mishra, Sourav; Singh, Rohit Kumar; Siddiqui, Nazia; Bal, Rajaram; Mandal, Dindyal

doi:10.1016/j.ijpharm.2019.04.007

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…For this, the authors used fluorescently labeled siRNA and proved its high intracellular accumulation in human colon cancer cells (HCT 116). More interesting was that they demonstrated successful gene silencing with transfection efficiencies comparable to commercially available Lipofectamine 2000 [106]. Notably, this is one of the rare studies in which successful drug delivery was obtained even in the presence of serum, proving again the favorable cooperation of CPPs and, in this case, anisotropic gold NPs.…”

Section: Cancer Therapymentioning

confidence: 91%

“…Within all these examples of CPP-NP conjugates, the role of the CPP was to achieve increased target site accumulation, as well as to improve overall cellular uptake. Remarkably, independent of the CPP attached, even when novel CPP sequences were used as, for instance, in the study of Panigrahi et al [106], enhanced membrane translocations were observed for NPs. Additionally, it is apparent that, in most cases, the applied CPPs were of cationic nature, a property that is probably key to lower the negative potential of certain NPs and, thus, to improve membrane surface interaction that is important for a successful uptake process (see chapter 2.2).…”

Section: Cancer Therapymentioning

confidence: 99%

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Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Gessner

Neundorf

2020

IJMS

146

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Based on their tunable physicochemical properties and the possibility of producing cell-specific platforms through surface modification with functional biomolecules, nanoparticles (NPs) represent highly promising tools for biomedical applications. To improve their potential under physiological conditions and to enhance their cellular uptake, combinations with cell-penetrating peptides (CPPs) represent a valuable strategy. CPPs are often cationic peptide sequences that are able to translocate across biological membranes and to carry attached cargos inside cells and have thus been recognized as versatile tools for drug delivery. Nevertheless, the conjugation of CPP to NP surfaces is dependent on many properties from both individual components, and further insight into this complex interplay is needed to allow for the fabrication of highly stable but functional vectors. Since CPPs per se are nonselective and enter nearly all cells likewise, additional decoration of NPs with homing devices, such as tumor-homing peptides, enables the design of multifunctional platforms for the targeted delivery of chemotherapeutic drugs. In this review, we have updated the recent advances in the field of CPP-NPs, focusing on synthesis strategies, elucidating the influence of different physicochemical properties, as well as their application in cancer research.

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Section: Cancer Therapymentioning

confidence: 91%

Section: Cancer Therapymentioning

confidence: 99%

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Gessner

Neundorf

2020

IJMS

146

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“…Based on the latest studies of the peptide-functionalized gold nanoparticles (peptide-GNPs) on delivering drugs, siRNA, imaging, etc. [39,[42][43][44], there are sufficient reasons to look forward to their prospective delivery and medical imaging applications in the treatment of osteosarcoma and BTE.…”

Section: The Modification Of Amino Acidsmentioning

confidence: 99%

Advances in the application of gold nanoparticles in bone tissue engineering

Xia

et al. 2020

J Biol Eng

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The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and functionalized, have attracted increasing attention. Recent years have witnessed this amazing material, i.e., GNPs characterized with large surface area to volume ratio, biocompatibility, medical imaging property, hypotoxicity, translocation into the cells, high reactivity, and other properties, perform distinct functions in BTE. However, the low stability of GNPs in the biotic environment makes them in the requirements of modification or recombination before being used. After being combined with the advantages of other materials, the structures of GNPs have exhibited great potential in stem cells, scaffolds, delivery systems, medical imaging, and other aspects. This review will focus on the advances in the application of GNPs after modification or recombination with other materials to BTE.

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“…In other strategies, photoreduction is used, and several examples have been described for the in situ formation for instance of silver NPs [40][41][42]. Additionally, the photoreduction of gold can be performed on the surface of peptides as capping agents to stabilize the resulting NPs, for application in the biochemical field, such as siRNA vectors for oncotherapy [43]. Either strategy is particularly attractive as it permits to avoid the use of polluting chemical reagents or harsh reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

“…for oncotherapy [43]. Either strategy is particularly attractive as it permits to avoid the use of polluting chemical reagents or harsh reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

Peptide Gelators to Template Inorganic Nanoparticle Formation

Bellotto

Cringoli

Perathoner

et al. 2021

Gels

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The use of peptides to template inorganic nanoparticle formation has attracted great interest as a green route to advance structures with innovative physicochemical properties for a variety of applications that range from biomedicine and sensing, to catalysis. In particular, short-peptide gelators offer the advantage of providing dynamic supramolecular environments for the templating effect on the formation of inorganic nanoparticles directly in the resulting gels, and ideally without using further reductants or chemical reagents. This mini-review describes the recent progress in the field to outline future research directions towards dynamic functional materials that exploit the synergy between supramolecular chemistry, nanoscience, and the interface between organic and inorganic components for advanced performance.

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Peptide generated anisotropic gold nanoparticles as efficient siRNA vectors

Cited by 10 publications

References 33 publications

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy

Advances in the application of gold nanoparticles in bone tissue engineering

Peptide Gelators to Template Inorganic Nanoparticle Formation

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