Biochemical Pharmacology volume 80, issue 6, P778-785 2010 DOI: 10.1016/j.bcp.2010.05.020 View full text
Jamel El-Benna, Pham My-Chan Dang, Axel Périanin

Abstract: Phagocytes such as neutrophils, monocytes and macrophages play an essential role in host defenses against pathogens. To kill these pathogens, phagocytes produce and release large quantities of antimicrobial molecules such as reactive oxygen species (ROS), microbicidal peptides, and proteases. The enzyme responsible for ROS generation is called NADPH oxidase, or respiratory burst oxidase, and is composed of six proteins: gp91phox, p22phox, p47phox, p67phox, p40phox and Rac1/2. The vital importance of this enzym…

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