Peptide-based assemblies as immune checkpoint inhibitor delivery systems for enhanced immunotherapy

Deng, Zhenwei; Yuan, Cong-Shan; Wang, Ting; Chen, Xiguang; Liu, Ya

doi:10.1016/j.apmt.2021.101063

Cited by 5 publications

(3 citation statements)

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“…Immunotherapy is a significant treatment to eliminate cancer cells by activating the immune system and is considered the third revolution in cancer therapy. 52 Immunotherapy has been used in clinical treatments including ICB (immune checkpoint blockade), CAR-T (chimeric antigen receptor T-cell), and vaccine. [53][54][55] Among them, ICB is an effective approach, which kills cancer cells by co-inhibitory or co-stimulatory signals to regulate the activity of immune cells.…”

Section: Immune Checkpoint Blockadementioning

confidence: 99%

Applications of peptide-based nanomaterials in targeting cancer therapy

Sun,

Zhang,

et al. 2024

Biomater. Sci.

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Section: Immune Checkpoint Blockadementioning

confidence: 99%

Applications of peptide-based nanomaterials in targeting cancer therapy

Sun,

Zhang,

et al. 2024

Biomater. Sci.

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“…This alteration from nonimmunogenic to immunogenic cell death in cancer cells enhanced the release of DAMPs, leading to the activation of dendritic cells (DCs) in the tumor microenvironment. The maturation of DCs enhances the uptake and display of tumor-associated antigens, amplifies the activation and specialization of effector T cells, and improves the effectiveness of tumor immunity, − and achieves effective eradication of cancer cells. Pyruvate kinase M2 (PKM2) plays a critical role in maintaining the Warburg effect, and transcriptional activation, and impacts tumor progression, metastasis, and resistance to treatment .…”

Section: Biomedical Applicationmentioning

confidence: 99%

Self-Assembly of Peptides as an Alluring Approach toward Cancer Treatment and Imaging

Ghafoor,

Song,

Zhou

et al. 2024

ACS Biomater. Sci. Eng.

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Cancer is a severe threat to humans, as it is the second leading cause of death after cardiovascular diseases and still poses the biggest challenge in the world of medicine. Due to its higher mortality rates and resistance, it requires a more focused and productive approach to provide the solution for it. Many therapies promising to deliver favorable results, such as chemotherapy and radiotherapy, have come up with more negatives than positives. Therefore, a new class of medicinal solutions and a more targeted approach is of the essence. This review highlights the alluring properties, configurations, and self-assembly of peptide molecules which benefit the traditional approach toward cancer therapy while sparing the healthy cells in the process. As targeted drug delivery systems, self-assembled peptides offer a wide spectrum of conjugation, biocompatibility, degradability-controlled responsiveness, and biomedical applications, including cancer treatment and cancer imaging.

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“…The transition from non-immunogenic cell death to immunogenic cell death in cancer cells accelerated the release of DAMPs and further facilitated the activation of DCs in the tumor microenvironment (Scheme 1B). The maturation of DCs enhances the phagocytosis and presentation of tumor-related antigens, promotes the activation and differentiation of effector T cells, improves the efficacy of tumor immunity, [38][39][40][41] and achieves efficient killing and removal of cancer cells.…”

Section: Introductionmentioning

confidence: 99%