PEP-1–SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model

Inhibition of LPS-induced cyclooxygenase 2 and nitric oxide production by transduced PEP-1-PTEN fusion protein in Raw 264.7 macrophage cells

“…Also, we transduced PEP-1-SOD and PEP-1-CCS into neuronal cells and across the blood-brain barrier which efficiently protected against ischemic insults. Also, Tat-α-synuclein fusion protein protects against oxidative stress in vitro and in vivo (Eum et al, 2004b;Choi et al, 2005Choi et al, , 2006a.…”

Inhibition of LPS-induced nitric oxide production by transduced Tat-arginine deiminase fusion protein in Raw 264.7 cells

“…By using this protein transduction technology, we have reported that various fusion proteins were efficiently transduced into mammalian cells and animal tissues. These transduced fusion proteins markedly protected cells and http://bmbreports.org BMB reports tissues against reactive oxygen species (28)(29)(30)(31). Recently, we demonstrated that PTD fusion proteins or PTD signal peptides can be efficiently transduced into cells and maintain their enzymatic activities (32)(33)(34).…”

Transduced Tat-Annexin protein suppresses inflammation-associated gene expression in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells

“…Several small regions of proteins, called protein transduction domains (PTDs), have been developed to allow the delivery of exogenous proteins into living cells. In a previous study, we used this technology to show that various fusion proteins efficiently protect against cell death in vitro and in vivo (15)(16)(17)(18)(19)(20). In the present study, we examined the inhibitory effects of Tat-ANX1 protein against LPS-induced inflammation-associated gene expression in murin macrophage Raw 264.7 cells.…”