Pentoxifylline (Trental) therapy for the vasculitis of atrophie blanche

Sauer, G. C.

doi:10.1001/archderm.122.4.380

Cited by 17 publications

(10 citation statements)

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“…Aspirin, pentoxifylline, prostacyclin, tissue plasminogen activator, low-dose heparin, dipyridamole, nicotinic acid, and phenformin have been tried with variable outcome. [17][18][19][20] Choi and Hann 21 reported two patients with LV that responded to systemic psoralen plus ultraviolet A (PUVA) with methoxsalen. Hsiao and Chiu 22 conducted a clinical trial with Danazol, a synthetic androgen with potential fibrinolytic effect, in 7 patients with LV.…”

Section: Discussionmentioning

confidence: 99%

Pulsed intravenous immunoglobulin therapy in livedoid vasculitis: An open trial evaluating 9 consecutive patients

Kreuter¹,

Gambichler²,

Breuckmann³

et al. 2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Pulsed intravenous immunoglobulin therapy in livedoid vasculitis: An open trial evaluating 9 consecutive patients

Kreuter¹,

Gambichler²,

Breuckmann³

et al. 2004

Journal of the American Academy of Dermatology

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“…5 These studies suggest that the thrombosis found to occur in livedoid vasculitis is part of a primary pathophysiological mechanism. In addition, a number of patients with livedoid vasculitis have responded to antithrombotic and antifibrinolytic agents including heparin, 19 tPA, 11,21 pentoxyphylline, 8,9,33,34 aspirin and dipyridamole, 8,20 long-term anticoagulants, 6,12 danazol, 17,38 ketanserin, 32 beraprost, 37 and prostacyclin. 16 A single report of intravenous immunoglobulin in livedoid vasculitis suggested a possible response.…”

Section: Discussionmentioning

confidence: 99%

Mononeuropathy multiplex in association with livedoid vasculitis

et al. 2003

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Livedoid vasculitis is a chronic dermatological disorder associated with petechiae and recurrent, unusually shaped ulcers that heal to form hyperpigmentated areas and atrophie blanche. This condition is more correctly termed a vasculopathy, rather than a vascultis, and is often associated with an underlying hypercoagulable disorder. We report a patient with livedoid vasculitis and mononeuropathy multiplex. We propose that peripheral nervous system involvement arises from multifocal areas of ischemia due to fibrin and thrombin deposition within both the wall and lumen of vasa nervorum.

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“…The most widely used initial treatments include aspirin, dipyridamole, subcutaneous heparin, and pentoxifylline. [17][18][19] Also, clinical improvement has been achieved with the use of danazol, 20 tissue plasminogen activator, 21 nifedipine, 22 sulfasalazine, 23 ketanserin, 24 intravenous immunoglobulin, 25 and psoralen-UV-A. 26 Our patient's lesions were unresponsive to a variety of treatments, including aspirin, dipyridamole, pentoxifylline, hydroxychloroquine, and prednisone.…”

Section: Commentmentioning

confidence: 99%